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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLDN16 All Species: 12.12
Human Site: T293 Identified Species: 29.63
UniProt: Q9Y5I7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y5I7 NP_006571.1 305 33836 T293 K S Y S A P R T E T A K M Y A
Chimpanzee Pan troglodytes XP_001161102 305 33850 T293 K S Y S A P R T E T A K M Y A
Rhesus Macaque Macaca mulatta XP_001093252 235 26008 E224 S Y S A A R T E T A K M Y A V
Dog Lupus familis XP_850268 286 31702 T274 K S Y A A P R T E T A K M Y A
Cat Felis silvestris
Mouse Mus musculus Q925N4 235 26081 E224 S Y K A P R T E T A K M Y A V
Rat Rattus norvegicus Q91Y55 235 26072 E224 S Y K A P R T E T A K M Y A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512461 252 27453 T241 V A A S V A V T V A A A V P V
Chicken Gallus gallus XP_426702 247 27291 A236 H L P S S Q T A T A K M Y A V
Frog Xenopus laevis NP_001087995 210 22636 Q199 R G Q Q Y Y R Q S Q P S A T T
Zebra Danio Brachydanio rerio Q9YH92 215 22846 S204 K S S R P V K S S R P P S S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 73.4 76.3 N.A. 71.4 71.1 N.A. 51.7 62.6 25.5 22.6 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.3 74.4 80.9 N.A. 73.7 73.4 N.A. 62.2 69.8 37.7 32.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 6.6 93.3 N.A. 0 0 N.A. 20 6.6 6.6 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 6.6 6.6 N.A. 33.3 13.3 13.3 33.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 10 40 40 10 0 10 0 50 40 10 10 40 30 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 30 30 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 40 0 20 0 0 0 10 0 0 0 40 30 0 0 0 % K
% Leu: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 40 30 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 10 0 30 30 0 0 0 0 20 10 0 10 0 % P
% Gln: 0 0 10 10 0 10 0 10 0 10 0 0 0 0 0 % Q
% Arg: 10 0 0 10 0 30 40 0 0 10 0 0 0 0 0 % R
% Ser: 30 40 20 40 10 0 0 10 20 0 0 10 10 10 10 % S
% Thr: 0 0 0 0 0 0 40 40 40 30 0 0 0 10 10 % T
% Val: 10 0 0 0 10 10 10 0 10 0 0 0 10 0 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 30 30 0 10 10 0 0 0 0 0 0 40 30 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _