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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IPP All Species: 24.55
Human Site: T574 Identified Species: 45
UniProt: Q9Y573 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y573 NP_005888.1 584 65261 T574 T E I G N M I T S R C E G G V
Chimpanzee Pan troglodytes XP_001159408 556 62209 L548 R S S S H D F L A P G W S A K
Rhesus Macaque Macaca mulatta XP_001104247 584 65184 T574 T E I G N M I T S R C E G G V
Dog Lupus familis XP_532595 584 65251 T574 T E I G N M I T S R C E G G V
Cat Felis silvestris
Mouse Mus musculus P28575 584 65323 T574 T E I G N M I T S R C E G G V
Rat Rattus norvegicus Q8R2H4 568 63244 D559 S M G T Q R C D A G V C V L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508662 584 65477 T574 T E I G N M I T S R C E G G V
Chicken Gallus gallus XP_422442 611 67297 T601 T E I A N M I T S R C E G G V
Frog Xenopus laevis Q6NRH0 564 63190 D555 S M A T Q R C D A G V C V L R
Zebra Danio Brachydanio rerio Q5U374 564 62914 A556 M A T Q R C D A G V C V L R E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUU5 623 68905 A605 G G V G V M R A P Q T E N Y M
Honey Bee Apis mellifera XP_001120870 595 66312 T583 H E C A S L P T S R G E A A A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797770 583 65047 V573 I D L G R M T V G R C E A A V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 98.9 97.2 N.A. 87.6 36.2 N.A. 91.4 79.5 36.1 34.5 N.A. 34.3 38.9 N.A. 45
Protein Similarity: 100 95.2 99.8 98.9 N.A. 92.1 53.5 N.A. 95.5 87.4 53.5 53.2 N.A. 51.6 56.8 N.A. 61.6
P-Site Identity: 100 0 100 100 N.A. 100 0 N.A. 100 93.3 0 6.6 N.A. 20 33.3 N.A. 40
P-Site Similarity: 100 13.3 100 100 N.A. 100 13.3 N.A. 100 93.3 13.3 6.6 N.A. 40 46.6 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 16 0 0 0 16 24 0 0 0 16 24 8 % A
% Cys: 0 0 8 0 0 8 16 0 0 0 62 16 0 0 0 % C
% Asp: 0 8 0 0 0 8 8 16 0 0 0 0 0 0 0 % D
% Glu: 0 54 0 0 0 0 0 0 0 0 0 70 0 0 8 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 8 54 0 0 0 0 16 16 16 0 47 47 0 % G
% His: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 47 0 0 0 47 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % K
% Leu: 0 0 8 0 0 8 0 8 0 0 0 0 8 16 0 % L
% Met: 8 16 0 0 0 62 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 0 47 0 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 8 0 8 8 0 0 0 0 0 % P
% Gln: 0 0 0 8 16 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 8 0 0 0 16 16 8 0 0 62 0 0 0 8 16 % R
% Ser: 16 8 8 8 8 0 0 0 54 0 0 0 8 0 0 % S
% Thr: 47 0 8 16 0 0 8 54 0 0 8 0 0 0 0 % T
% Val: 0 0 8 0 8 0 0 8 0 8 16 8 16 0 54 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _