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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMACHC
All Species:
12.73
Human Site:
T253
Identified Species:
28
UniProt:
Q9Y4U1
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y4U1
NP_056321.2
282
31728
T253
P
S
P
D
L
P
F
T
T
P
A
P
K
K
P
Chimpanzee
Pan troglodytes
XP_524565
282
31738
T253
P
S
P
D
L
P
F
T
T
P
A
P
K
K
P
Rhesus Macaque
Macaca mulatta
XP_001102924
282
31797
T253
P
S
P
D
F
P
F
T
T
H
T
P
K
K
P
Dog
Lupus familis
XP_539631
348
38926
T320
P
S
P
E
L
P
F
T
F
R
P
K
K
P
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9CZD0
279
31630
P250
P
S
T
T
S
E
L
P
L
S
L
L
T
K
P
Rat
Rattus norvegicus
NP_001101432
279
31489
P250
P
S
T
T
S
E
H
P
L
S
L
L
T
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515251
297
32837
S238
H
V
R
I
L
Q
E
S
Y
C
N
A
A
G
G
Chicken
Gallus gallus
Q5ZL21
238
27618
E210
R
D
I
I
E
V
K
E
R
Y
S
E
E
Q
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RFU5
250
28697
S221
V
P
A
E
D
R
Y
S
D
Q
Q
K
Q
Y
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q7Z144
272
31272
R239
R
D
F
G
N
P
T
R
R
Y
S
T
T
Q
M
Sea Urchin
Strong. purpuratus
XP_780527
245
28176
A217
Q
I
C
Y
W
N
T
A
P
S
K
R
F
A
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96
71.5
N.A.
83.6
82.6
N.A.
41
51.7
N.A.
42.2
N.A.
N.A.
N.A.
31.9
39.3
Protein Similarity:
100
99.6
96.8
74.7
N.A.
89.3
88.3
N.A.
48.1
65.5
N.A.
57
N.A.
N.A.
N.A.
49.2
56
P-Site Identity:
100
100
80
53.3
N.A.
26.6
26.6
N.A.
6.6
0
N.A.
0
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
80
60
N.A.
26.6
26.6
N.A.
13.3
20
N.A.
26.6
N.A.
N.A.
N.A.
20
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
10
0
0
19
10
10
10
0
% A
% Cys:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
19
0
28
10
0
0
0
10
0
0
0
0
0
0
% D
% Glu:
0
0
0
19
10
19
10
10
0
0
0
10
10
0
0
% E
% Phe:
0
0
10
0
10
0
37
0
10
0
0
0
10
0
10
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
10
% G
% His:
10
0
0
0
0
0
10
0
0
10
0
0
0
0
0
% H
% Ile:
0
10
10
19
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
10
19
37
46
10
% K
% Leu:
0
0
0
0
37
0
10
0
19
0
19
19
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
10
10
0
0
0
0
10
0
0
0
0
% N
% Pro:
55
10
37
0
0
46
0
19
10
19
10
28
0
10
46
% P
% Gln:
10
0
0
0
0
10
0
0
0
10
10
0
10
19
10
% Q
% Arg:
19
0
10
0
0
10
0
10
19
10
0
10
0
0
0
% R
% Ser:
0
55
0
0
19
0
0
19
0
28
19
0
0
0
0
% S
% Thr:
0
0
19
19
0
0
19
37
28
0
10
10
28
0
0
% T
% Val:
10
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
10
0
10
19
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _