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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMACHC
All Species:
12.42
Human Site:
S244
Identified Species:
27.33
UniProt:
Q9Y4U1
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y4U1
NP_056321.2
282
31728
S244
A
Q
P
S
E
K
P
S
S
P
S
P
D
L
P
Chimpanzee
Pan troglodytes
XP_524565
282
31738
S244
A
Q
P
S
E
K
P
S
S
P
S
P
D
L
P
Rhesus Macaque
Macaca mulatta
XP_001102924
282
31797
S244
V
Q
P
S
E
K
P
S
S
P
S
P
D
F
P
Dog
Lupus familis
XP_539631
348
38926
S311
A
Q
P
S
K
D
T
S
S
P
S
P
E
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9CZD0
279
31630
E241
L
G
L
A
Q
P
S
E
H
P
S
T
T
S
E
Rat
Rattus norvegicus
NP_001101432
279
31489
G241
L
G
L
A
Q
P
S
G
H
P
S
T
T
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515251
297
32837
E229
A
G
S
S
K
N
L
E
S
H
V
R
I
L
Q
Chicken
Gallus gallus
Q5ZL21
238
27618
R201
N
F
H
W
Q
D
G
R
Y
R
D
I
I
E
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5RFU5
250
28697
D212
W
R
D
W
S
Y
R
D
I
V
P
A
E
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q7Z144
272
31272
G230
N
Y
N
W
K
D
S
G
F
R
D
F
G
N
P
Sea Urchin
Strong. purpuratus
XP_780527
245
28176
P208
P
A
Q
D
K
Y
S
P
E
Q
I
C
Y
W
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96
71.5
N.A.
83.6
82.6
N.A.
41
51.7
N.A.
42.2
N.A.
N.A.
N.A.
31.9
39.3
Protein Similarity:
100
99.6
96.8
74.7
N.A.
89.3
88.3
N.A.
48.1
65.5
N.A.
57
N.A.
N.A.
N.A.
49.2
56
P-Site Identity:
100
100
86.6
73.3
N.A.
13.3
13.3
N.A.
26.6
0
N.A.
0
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
86.6
86.6
N.A.
26.6
26.6
N.A.
33.3
6.6
N.A.
13.3
N.A.
N.A.
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
37
10
0
19
0
0
0
0
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
0
0
10
10
0
28
0
10
0
0
19
0
28
10
0
% D
% Glu:
0
0
0
0
28
0
0
19
10
0
0
0
19
10
19
% E
% Phe:
0
10
0
0
0
0
0
0
10
0
0
10
0
10
0
% F
% Gly:
0
28
0
0
0
0
10
19
0
0
0
0
10
0
0
% G
% His:
0
0
10
0
0
0
0
0
19
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
10
10
19
0
0
% I
% Lys:
0
0
0
0
37
28
0
0
0
0
0
0
0
0
0
% K
% Leu:
19
0
19
0
0
0
10
0
0
0
0
0
0
37
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
0
10
0
0
10
0
0
0
0
0
0
0
10
10
% N
% Pro:
10
0
37
0
0
19
28
10
0
55
10
37
0
0
46
% P
% Gln:
0
37
10
0
28
0
0
0
0
10
0
0
0
0
10
% Q
% Arg:
0
10
0
0
0
0
10
10
0
19
0
10
0
0
10
% R
% Ser:
0
0
10
46
10
0
37
37
46
0
55
0
0
19
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
19
19
0
0
% T
% Val:
10
0
0
0
0
0
0
0
0
10
10
0
0
0
10
% V
% Trp:
10
0
0
28
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
10
0
0
0
19
0
0
10
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _