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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WIPI2 All Species: 6.06
Human Site: S388 Identified Species: 12.12
UniProt: Q9Y4P8 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y4P8 NP_001028690.1 454 49408 S388 T T N E I L D S A S H D C P L
Chimpanzee Pan troglodytes XP_001165276 446 48667 S380 L R P S L P Q S Y A A T V A R
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850630 436 47691 A371 T N E I L D S A S H D C P L V
Cat Felis silvestris
Mouse Mus musculus Q80W47 445 48459 T379 S H D C P L A T Q T Y G T A A
Rat Rattus norvegicus Q6AY57 445 48501 T379 S H D C P L V T Q T Y G T A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512711 416 45669 A352 L D G S M E P A N E I L E S A
Chicken Gallus gallus Q5ZHN3 436 47757 A371 A N E I L E S A S H D R P L V
Frog Xenopus laevis Q7ZWU5 435 47675 S371 S S E I L E S S S H D R Q V G
Zebra Danio Brachydanio rerio Q7ZUW6 344 38148 F280 A S F L P K Y F S S K W S F S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_624581 392 43147 L328 V V H K V L R L L V A S A E G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781358 486 52131 G414 K T F A S A T G G S R N V D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q96U88 461 50001 G397 K S S N N R A G G L S A T P L
Conservation
Percent
Protein Identity: 100 55 N.A. 91.8 N.A. 93.1 93.6 N.A. 86.5 91.1 85 26.8 N.A. N.A. 61.4 N.A. 63.7
Protein Similarity: 100 72.6 N.A. 93.8 N.A. 94.7 94.9 N.A. 88.5 93.1 90.3 40.5 N.A. N.A. 72 N.A. 73
P-Site Identity: 100 6.6 N.A. 6.6 N.A. 6.6 6.6 N.A. 0 0 6.6 6.6 N.A. N.A. 6.6 N.A. 20
P-Site Similarity: 100 20 N.A. 33.3 N.A. 40 40 N.A. 13.3 26.6 33.3 20 N.A. N.A. 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 26.4
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 45.3
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 9 0 9 17 25 9 9 17 9 9 25 25 % A
% Cys: 0 0 0 17 0 0 0 0 0 0 0 9 9 0 0 % C
% Asp: 0 9 17 0 0 9 9 0 0 0 25 9 0 9 0 % D
% Glu: 0 0 25 9 0 25 0 0 0 9 0 0 9 9 0 % E
% Phe: 0 0 17 0 0 0 0 9 0 0 0 0 0 9 0 % F
% Gly: 0 0 9 0 0 0 0 17 17 0 0 17 0 0 17 % G
% His: 0 17 9 0 0 0 0 0 0 25 9 0 0 0 0 % H
% Ile: 0 0 0 25 9 0 0 0 0 0 9 0 0 0 0 % I
% Lys: 17 0 0 9 0 9 0 0 0 0 9 0 0 0 0 % K
% Leu: 17 0 0 9 34 34 0 9 9 9 0 9 0 17 25 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 17 9 9 9 0 0 0 9 0 0 9 0 0 0 % N
% Pro: 0 0 9 0 25 9 9 0 0 0 0 0 17 17 0 % P
% Gln: 0 0 0 0 0 0 9 0 17 0 0 0 9 0 0 % Q
% Arg: 0 9 0 0 0 9 9 0 0 0 9 17 0 0 9 % R
% Ser: 25 25 9 17 9 0 25 25 34 25 9 9 9 9 9 % S
% Thr: 17 17 0 0 0 0 9 17 0 17 0 9 25 0 0 % T
% Val: 9 9 0 0 9 0 9 0 0 9 0 0 17 9 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 9 0 9 0 17 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _