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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK1B
All Species:
30.61
Human Site:
Y64
Identified Species:
67.33
UniProt:
Q9Y463
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y463
NP_004705.1
629
69198
Y64
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089972
629
69208
Y64
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Dog
Lupus familis
XP_853246
689
75066
Y124
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z188
629
69160
Y64
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Rat
Rattus norvegicus
Q63470
763
85522
Y112
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509695
797
89233
Y146
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
Frog
Xenopus laevis
Q2TAE3
750
84138
Y104
K
H
I
N
E
V
Y
Y
A
K
K
K
R
R
H
Zebra Danio
Brachydanio rerio
XP_684056
681
76846
Y64
K
H
I
N
E
V
Y
Y
T
K
K
K
R
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49657
908
95884
A117
H
I
N
E
V
Y
Y
A
K
K
K
R
R
A
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.5
90.2
N.A.
97.3
54.7
N.A.
52.7
32.1
55.4
64.7
N.A.
45.1
N.A.
N.A.
N.A.
Protein Similarity:
100
N.A.
99.6
90.5
N.A.
97.9
64.4
N.A.
61.7
46
65.3
72.2
N.A.
54.1
N.A.
N.A.
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
93.3
N.A.
93.3
0
93.3
93.3
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
93.3
N.A.
93.3
0
93.3
93.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
64
0
0
0
0
10
46
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
10
73
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
10
73
0
0
0
0
0
0
0
0
0
0
0
0
28
% H
% Ile:
0
10
73
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
73
0
0
0
0
0
0
0
10
82
82
73
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
73
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
10
82
73
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% T
% Val:
0
0
0
0
10
73
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
82
73
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _