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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADAM18
All Species:
10.91
Human Site:
S20
Identified Species:
34.29
UniProt:
Q9Y3Q7
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Q7
NP_055052.1
739
82856
S20
R
L
Q
A
H
E
G
S
E
G
I
F
L
H
V
Chimpanzee
Pan troglodytes
XP_519721
739
82738
S20
R
L
Q
A
H
E
G
S
E
G
I
F
L
H
V
Rhesus Macaque
Macaca mulatta
XP_001095172
855
95089
N89
A
S
R
R
G
F
Q
N
S
L
L
Q
I
V
I
Dog
Lupus familis
XP_849584
816
91682
S110
R
L
H
A
R
L
D
S
E
G
I
L
L
H
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9R157
719
79145
S19
M
L
F
A
R
L
D
S
E
G
I
C
L
H
I
Rat
Rattus norvegicus
P97776
445
48181
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517253
692
76612
V21
K
K
A
T
S
L
V
V
Q
V
N
Q
V
H
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001079073
873
95243
Y41
Q
T
S
F
L
S
S
Y
N
I
I
I
P
Q
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.1
36.1
68.6
N.A.
60.7
38.2
N.A.
40.5
N.A.
29.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.5
54.7
76.9
N.A.
76.4
47.9
N.A.
58.4
N.A.
46.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
66.6
N.A.
53.3
0
N.A.
6.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
33.3
66.6
N.A.
60
0
N.A.
26.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
0
13
50
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% C
% Asp:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
25
0
0
50
0
0
0
0
0
0
% E
% Phe:
0
0
13
13
0
13
0
0
0
0
0
25
0
0
0
% F
% Gly:
0
0
0
0
13
0
25
0
0
50
0
0
0
0
0
% G
% His:
0
0
13
0
25
0
0
0
0
0
0
0
0
63
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
13
63
13
13
0
25
% I
% Lys:
13
13
0
0
0
0
0
0
0
0
0
0
0
0
25
% K
% Leu:
0
50
0
0
13
38
0
0
0
13
13
13
50
0
0
% L
% Met:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
13
13
0
13
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% P
% Gln:
13
0
25
0
0
0
13
0
13
0
0
25
0
13
0
% Q
% Arg:
38
0
13
13
25
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
13
13
0
13
13
13
50
13
0
0
0
0
0
0
% S
% Thr:
0
13
0
13
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
13
13
0
13
0
0
13
13
38
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _