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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HPSE All Species: 25.76
Human Site: S219 Identified Species: 56.67
UniProt: Q9Y251 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y251 NP_001092010.1 543 61177 S219 S S K G Y N I S W E L G N E P
Chimpanzee Pan troglodytes XP_517183 543 61209 S219 S S K G Y N I S W E L G N E P
Rhesus Macaque Macaca mulatta XP_001104975 545 61334 S221 S S K R Y N M S W E L G N E P
Dog Lupus familis XP_850908 545 61071 S221 S S K N Y N I S W E L G N E P
Cat Felis silvestris
Mouse Mus musculus Q6YGZ1 535 60032 S211 S S K G Y N I S W E L G N E P
Rat Rattus norvegicus Q71RP1 536 60461 S212 S S K G Y N I S W E L G N E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YK5 523 58368 R209 G N E P N S F R K K S G I C I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038470 546 60923 S217 E S R Q Y M M S W E L G N E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121450 528 60132 P210 D W Q L G N E P N S F N H V F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791694 477 53110 Q164 T L R K S V S Q I P E L T D I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FF10 543 60232 L220 A E L Y G K D L I V L K D V I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 95 82.7 N.A. 76.8 75.8 N.A. N.A. 60.2 N.A. 50.9 N.A. N.A. 30.3 N.A. 30.3
Protein Similarity: 100 99.2 97.2 89.5 N.A. 85.2 84.7 N.A. N.A. 76.4 N.A. 68.5 N.A. N.A. 47.7 N.A. 47.7
P-Site Identity: 100 100 86.6 93.3 N.A. 100 100 N.A. N.A. 6.6 N.A. 66.6 N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 100 93.3 93.3 N.A. 100 100 N.A. N.A. 33.3 N.A. 80 N.A. N.A. 20 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 28.1 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 10 0 0 0 0 0 10 0 0 0 0 0 10 10 0 % D
% Glu: 10 10 10 0 0 0 10 0 0 64 10 0 0 64 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 10 0 0 0 10 % F
% Gly: 10 0 0 37 19 0 0 0 0 0 0 73 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 0 0 0 0 46 0 19 0 0 0 10 0 28 % I
% Lys: 0 0 55 10 0 10 0 0 10 10 0 10 0 0 0 % K
% Leu: 0 10 10 10 0 0 0 10 0 0 73 10 0 0 0 % L
% Met: 0 0 0 0 0 10 19 0 0 0 0 0 0 0 0 % M
% Asn: 0 10 0 10 10 64 0 0 10 0 0 10 64 0 0 % N
% Pro: 0 0 0 10 0 0 0 10 0 10 0 0 0 0 64 % P
% Gln: 0 0 10 10 0 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 19 10 0 0 0 10 0 0 0 0 0 0 0 % R
% Ser: 55 64 0 0 10 10 10 64 0 10 10 0 0 0 0 % S
% Thr: 10 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % T
% Val: 0 0 0 0 0 10 0 0 0 10 0 0 0 19 0 % V
% Trp: 0 10 0 0 0 0 0 0 64 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 64 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _