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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC3 All Species: 30.91
Human Site: S1013 Identified Species: 48.57
UniProt: Q9UQE7 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UQE7 NP_005436.1 1217 141542 S1013 E L D R G Y K S I M E L M N V
Chimpanzee Pan troglodytes XP_508031 1374 158072 S1170 E L D R G Y K S I M E L M N V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851818 1228 142683 S1024 E L D R G Y K S I M E L M N V
Cat Felis silvestris
Mouse Mus musculus Q9CW03 1217 141537 S1013 E L D R G Y K S I M E L M N V
Rat Rattus norvegicus P97690 1191 138430 S980 N T E L K K Y S H V N K K A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512851 1238 143475 S1034 E L D R G Y K S I M E L M N V
Chicken Gallus gallus Q90988 1189 134923 L983 K E K L E K S L N M R A M N L
Frog Xenopus laevis O93309 1209 140704 E1005 E K L I K R Q E E L D R G H K
Zebra Danio Brachydanio rerio NP_999854 1216 141517 S1013 E L D R G Y K S I M E L M N V
Tiger Blowfish Takifugu rubipres NP_001027798 1217 141541 S1013 E L D R G Y K S I M E L M N V
Fruit Fly Dros. melanogaster NP_523374 1200 140018 K996 F L S F S E Q K E K L Y R R K
Honey Bee Apis mellifera XP_393700 1202 139436 E998 M S F S D Q K E K L V K R K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001202053 792 92535 Y596 G D T L A N I Y K H V F G K T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SN90 1171 132296 R966 K A R E E L E R L Q T D Q S S
Baker's Yeast Sacchar. cerevisiae P47037 1230 141318 S1025 E L D E S K D S I Q D L I V K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.5 N.A. 99 N.A. 99.9 97.2 N.A. 97.5 23.3 95.8 95.1 94.9 53.4 55.4 N.A. 40.1
Protein Similarity: 100 88.5 N.A. 99 N.A. 100 97.4 N.A. 98 46.5 97.6 97.5 97.3 73.2 72.9 N.A. 53.9
P-Site Identity: 100 100 N.A. 100 N.A. 100 6.6 N.A. 100 20 6.6 100 100 6.6 6.6 N.A. 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 26.6 N.A. 100 33.3 33.3 100 100 13.3 13.3 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 24 33.1 N.A.
Protein Similarity: N.A. N.A. N.A. 47 57.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 7 0 0 0 0 0 0 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 54 0 7 0 7 0 0 0 14 7 0 0 0 % D
% Glu: 60 7 7 14 14 7 7 14 14 0 47 0 0 0 7 % E
% Phe: 7 0 7 7 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 7 0 0 0 47 0 0 0 0 0 0 0 14 0 0 % G
% His: 0 0 0 0 0 0 0 0 7 7 0 0 0 7 0 % H
% Ile: 0 0 0 7 0 0 7 0 54 0 0 0 7 0 0 % I
% Lys: 14 7 7 0 14 20 54 7 14 7 0 14 7 14 20 % K
% Leu: 0 60 7 20 0 7 0 7 7 14 7 54 0 0 14 % L
% Met: 7 0 0 0 0 0 0 0 0 54 0 0 54 0 0 % M
% Asn: 7 0 0 0 0 7 0 0 7 0 7 0 0 54 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 7 14 0 0 14 0 0 7 0 0 % Q
% Arg: 0 0 7 47 0 7 0 7 0 0 7 7 14 7 0 % R
% Ser: 0 7 7 7 14 0 7 60 0 0 0 0 0 7 7 % S
% Thr: 0 7 7 0 0 0 0 0 0 0 7 0 0 0 7 % T
% Val: 0 0 0 0 0 0 0 0 0 7 14 0 0 7 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 47 7 7 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _