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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
36.36
Human Site:
T566
Identified Species:
61.54
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
T566
N
Y
I
M
L
A
D
T
D
K
I
K
S
F
E
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
T566
N
Y
I
M
L
A
D
T
D
K
I
K
S
F
E
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
T566
N
Y
I
M
L
A
D
T
D
K
M
K
S
F
E
Dog
Lupus familis
XP_537547
1923
218622
T566
N
Y
I
M
L
A
D
T
D
K
I
K
S
F
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
T566
N
Y
V
M
L
A
D
T
D
K
I
K
S
F
E
Rat
Rattus norvegicus
XP_001068155
1918
216871
T566
N
Y
V
M
L
A
D
T
D
K
I
K
S
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
S566
N
Y
I
M
L
A
D
S
D
K
I
V
T
F
E
Chicken
Gallus gallus
Q25BN1
1921
218592
T566
N
Y
I
M
L
A
D
T
D
K
I
K
S
F
E
Frog
Xenopus laevis
NP_001163918
1795
204583
Q485
K
N
Q
P
R
N
K
Q
M
E
V
E
F
R
K
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
S552
N
Y
I
M
L
A
D
S
E
R
T
K
T
F
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
A761
I
D
T
A
H
S
L
A
S
T
T
K
D
L
V
Honey Bee
Apis mellifera
NP_001116485
1946
224489
Q560
L
Y
V
L
L
V
S
Q
E
M
S
K
E
Y
V
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
Y501
A
R
R
A
G
S
R
Y
V
I
T
V
E
E
K
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
R518
C
I
A
M
G
S
G
R
L
G
T
T
K
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
80
100
0
60
N.A.
6.6
20
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
26.6
93.3
N.A.
13.3
46.6
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
15
0
65
0
8
0
0
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
65
0
58
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
15
8
0
8
15
8
58
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
65
0
% F
% Gly:
0
0
0
0
15
0
8
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
50
0
0
0
0
0
0
8
50
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
8
0
0
58
0
72
8
8
15
% K
% Leu:
8
0
0
8
72
0
8
0
8
0
0
0
0
8
0
% L
% Met:
0
0
0
72
0
0
0
0
8
8
8
0
0
0
0
% M
% Asn:
65
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
15
0
0
0
0
0
0
8
% Q
% Arg:
0
8
8
0
8
0
8
8
0
8
0
0
0
8
0
% R
% Ser:
0
0
0
0
0
22
8
15
8
0
8
0
50
0
8
% S
% Thr:
0
0
8
0
0
0
0
50
0
8
29
8
15
0
0
% T
% Val:
0
0
22
0
0
8
0
0
8
0
8
15
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
72
0
0
0
0
0
8
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _