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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
33.64
Human Site:
S290
Identified Species:
56.92
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Dog
Lupus familis
XP_537547
1923
218622
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
S290
D
C
N
V
A
V
H
S
K
E
R
D
S
T
L
Rat
Rattus norvegicus
XP_001068155
1918
216871
S290
D
C
N
V
S
V
H
S
K
E
R
D
S
T
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
S290
D
C
N
I
T
V
L
S
K
E
R
D
S
T
L
Chicken
Gallus gallus
Q25BN1
1921
218592
S290
D
C
N
I
S
V
H
S
K
E
R
D
S
T
L
Frog
Xenopus laevis
NP_001163918
1795
204583
S254
C
G
P
Y
V
D
R
S
G
L
Y
Q
R
L
L
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
R276
D
C
N
L
S
V
H
R
E
D
R
D
P
T
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
S337
T
A
L
I
Q
L
Y
S
L
C
E
H
A
F
H
Honey Bee
Apis mellifera
NP_001116485
1946
224489
E277
D
P
T
E
K
P
F
E
M
M
Q
D
L
L
H
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
D267
T
T
T
E
F
H
P
D
L
D
L
D
P
R
R
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
E282
L
D
Q
L
N
Q
F
E
Y
S
F
K
A
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
86.6
100
13.3
60
N.A.
13.3
13.3
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
13.3
80
N.A.
33.3
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
0
0
0
0
15
0
0
% A
% Cys:
8
65
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
72
8
0
0
0
8
0
8
0
15
0
79
0
0
8
% D
% Glu:
0
0
0
15
0
0
0
15
8
58
8
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
15
0
0
0
8
0
0
8
8
% F
% Gly:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
58
0
0
0
0
8
0
0
15
% H
% Ile:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
58
0
0
8
0
0
0
% K
% Leu:
8
0
8
15
0
8
8
0
15
8
8
0
8
15
65
% L
% Met:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% M
% Asn:
0
0
65
0
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
8
0
0
8
8
0
0
0
0
0
15
0
0
% P
% Gln:
0
0
8
0
8
8
0
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
8
0
0
65
0
8
15
8
% R
% Ser:
0
0
0
0
50
0
0
72
0
8
0
0
58
0
0
% S
% Thr:
15
8
15
0
8
0
0
0
0
0
0
0
0
65
0
% T
% Val:
0
0
0
15
8
65
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
8
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _