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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
25.76
Human Site:
S1277
Identified Species:
43.59
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S1277
V
L
K
G
R
M
D
S
E
Q
S
P
S
I
G
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S1277
V
L
K
G
R
M
D
S
E
Q
S
P
S
I
G
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
S1275
V
L
K
G
R
M
D
S
E
Q
S
P
S
I
G
Dog
Lupus familis
XP_537547
1923
218622
S1278
A
L
K
D
K
M
G
S
E
Q
S
P
C
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
S1277
A
L
K
D
R
M
D
S
E
Q
S
P
S
V
G
Rat
Rattus norvegicus
XP_001068155
1918
216871
S1277
A
L
E
G
R
T
D
S
E
Q
S
P
S
V
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
S1278
A
S
K
D
P
I
V
S
E
R
S
P
S
N
E
Chicken
Gallus gallus
Q25BN1
1921
218592
S1278
L
S
K
D
K
V
D
S
E
K
N
T
S
S
G
Frog
Xenopus laevis
NP_001163918
1795
204583
I1172
D
C
K
A
I
N
G
I
T
C
N
G
L
T
N
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
K1239
P
T
S
K
H
C
P
K
S
E
T
A
T
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
P1481
D
D
D
D
N
A
G
P
L
N
Y
M
H
H
N
Honey Bee
Apis mellifera
NP_001116485
1946
224489
E1276
E
K
Q
I
S
K
Q
E
V
N
K
R
I
L
D
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
K1191
K
E
E
E
Q
F
K
K
L
Q
N
D
L
L
K
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
N1211
H
V
E
P
K
C
N
N
N
E
Q
L
K
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
100
60
N.A.
80
73.3
N.A.
40
40
6.6
0
N.A.
0
0
6.6
0
P-Site Similarity:
100
100
100
66.6
N.A.
86.6
86.6
N.A.
53.3
73.3
13.3
20
N.A.
0
13.3
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
0
0
8
0
8
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
8
0
0
0
15
0
0
0
8
0
0
8
0
0
% C
% Asp:
15
8
8
36
0
0
43
0
0
0
0
8
0
0
8
% D
% Glu:
8
8
22
8
0
0
0
8
58
15
0
0
0
8
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
29
0
0
22
0
0
0
0
8
0
0
50
% G
% His:
8
0
0
0
8
0
0
0
0
0
0
0
8
8
0
% H
% Ile:
0
0
0
8
8
8
0
8
0
0
0
0
8
22
0
% I
% Lys:
8
8
58
8
22
8
8
15
0
8
8
0
8
0
8
% K
% Leu:
8
43
0
0
0
0
0
0
15
0
0
8
15
15
0
% L
% Met:
0
0
0
0
0
36
0
0
0
0
0
8
0
0
8
% M
% Asn:
0
0
0
0
8
8
8
8
8
15
22
0
0
8
15
% N
% Pro:
8
0
0
8
8
0
8
8
0
0
0
50
0
8
0
% P
% Gln:
0
0
8
0
8
0
8
0
0
50
8
0
0
0
0
% Q
% Arg:
0
0
0
0
36
0
0
0
0
8
0
8
0
0
0
% R
% Ser:
0
15
8
0
8
0
0
58
8
0
50
0
50
15
0
% S
% Thr:
0
8
0
0
0
8
0
0
8
0
8
8
8
8
8
% T
% Val:
22
8
0
0
0
8
8
0
8
0
0
0
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _