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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
26.36
Human Site:
S1216
Identified Species:
44.62
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S1216
I
P
V
Q
P
T
T
S
Y
S
I
Q
N
L
Y
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S1216
I
P
V
Q
P
T
T
S
Y
S
I
Q
N
L
Y
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
T1214
Q
E
I
P
V
Q
P
T
T
S
Y
S
I
Q
N
Dog
Lupus familis
XP_537547
1923
218622
S1217
I
P
V
Q
P
T
T
S
Y
P
I
Q
N
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
S1216
I
P
V
Q
P
T
T
S
Y
P
I
Q
N
L
Y
Rat
Rattus norvegicus
XP_001068155
1918
216871
S1216
I
P
V
Q
P
T
T
S
Y
P
I
Q
N
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
S1217
I
P
I
Q
P
A
T
S
Y
P
M
Q
N
L
Y
Chicken
Gallus gallus
Q25BN1
1921
218592
S1217
I
P
V
Q
P
T
T
S
Y
P
I
Q
N
L
Y
Frog
Xenopus laevis
NP_001163918
1795
204583
E1111
S
F
S
A
V
E
R
E
S
D
C
R
L
S
I
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
V1178
D
L
P
H
R
S
D
V
C
Q
C
S
Q
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
R1420
K
F
C
D
Q
Q
T
R
Y
G
S
P
T
F
W
Honey Bee
Apis mellifera
NP_001116485
1946
224489
I1215
N
E
F
N
W
N
D
I
R
Y
G
S
P
A
C
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
D1130
D
W
D
G
P
E
P
D
N
S
P
M
P
F
Q
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
A1150
E
E
L
R
V
Q
V
A
E
E
A
G
I
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
6.6
93.3
N.A.
93.3
93.3
N.A.
73.3
93.3
0
6.6
N.A.
13.3
0
13.3
0
P-Site Similarity:
100
100
20
93.3
N.A.
93.3
93.3
N.A.
86.6
93.3
6.6
13.3
N.A.
20
0
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
8
0
0
8
0
0
8
0
% A
% Cys:
0
0
8
0
0
0
0
0
8
0
15
0
0
0
8
% C
% Asp:
15
0
8
8
0
0
15
8
0
8
0
0
0
0
0
% D
% Glu:
8
22
0
0
0
15
0
8
8
8
0
0
0
0
0
% E
% Phe:
0
15
8
0
0
0
0
0
0
0
0
0
0
15
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
8
8
8
0
8
8
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
50
0
15
0
0
0
0
8
0
0
43
0
15
0
8
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
8
0
0
0
0
0
0
0
0
0
8
58
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% M
% Asn:
8
0
0
8
0
8
0
0
8
0
0
0
50
0
8
% N
% Pro:
0
50
8
8
58
0
15
0
0
36
8
8
15
0
0
% P
% Gln:
8
0
0
50
8
22
0
0
0
8
0
50
8
8
8
% Q
% Arg:
0
0
0
8
8
0
8
8
8
0
0
8
0
0
0
% R
% Ser:
8
0
8
0
0
8
0
50
8
29
8
22
0
8
0
% S
% Thr:
0
0
0
0
0
43
58
8
8
0
0
0
8
0
0
% T
% Val:
0
0
43
0
22
0
8
8
0
0
0
0
0
0
0
% V
% Trp:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
58
8
8
0
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _