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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
8.48
Human Site:
S1158
Identified Species:
14.36
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S1158
V
N
C
R
T
L
L
S
E
S
P
G
K
L
H
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S1158
V
N
C
R
T
L
L
S
E
S
P
G
K
L
H
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
L1156
M
S
V
N
C
R
T
L
L
S
E
S
P
G
K
Dog
Lupus familis
XP_537547
1923
218622
S1159
V
N
C
R
T
L
F
S
E
S
P
G
K
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
A1158
V
N
C
K
R
L
P
A
E
S
P
A
K
L
Q
Rat
Rattus norvegicus
XP_001068155
1918
216871
A1158
V
N
C
K
R
L
P
A
E
S
P
A
K
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
N1159
V
N
Y
R
I
P
L
N
E
S
P
S
K
L
Q
Chicken
Gallus gallus
Q25BN1
1921
218592
D1159
V
S
Y
R
T
L
L
D
E
S
P
S
K
L
Q
Frog
Xenopus laevis
NP_001163918
1795
204583
L1053
L
P
S
I
L
Y
R
L
H
C
L
L
T
A
E
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
A1120
S
S
D
S
N
H
T
A
P
E
S
C
S
M
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
I1362
E
K
S
A
I
E
L
I
I
E
G
E
E
K
L
Honey Bee
Apis mellifera
NP_001116485
1946
224489
L1157
E
S
N
Y
E
F
Q
L
T
N
D
K
I
T
E
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
G1072
G
E
D
Q
D
T
V
G
L
T
Q
G
L
H
D
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
I1092
H
K
G
K
A
L
P
I
S
T
G
Q
N
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
6.6
86.6
N.A.
60
60
N.A.
60
66.6
0
0
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
20
86.6
N.A.
73.3
73.3
N.A.
66.6
73.3
6.6
20
N.A.
13.3
13.3
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
22
0
0
0
15
0
8
0
% A
% Cys:
0
0
36
0
8
0
0
0
0
8
0
8
0
0
0
% C
% Asp:
0
0
15
0
8
0
0
8
0
0
8
0
0
0
8
% D
% Glu:
15
8
0
0
8
8
0
0
50
15
8
8
8
0
22
% E
% Phe:
0
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
0
8
0
0
15
29
0
8
0
% G
% His:
8
0
0
0
0
8
0
0
8
0
0
0
0
8
15
% H
% Ile:
0
0
0
8
15
0
0
15
8
0
0
0
8
0
0
% I
% Lys:
0
15
0
22
0
0
0
0
0
0
0
8
50
15
15
% K
% Leu:
8
0
0
0
8
50
36
22
15
0
8
8
8
50
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
43
8
8
8
0
0
8
0
8
0
0
8
0
0
% N
% Pro:
0
8
0
0
0
8
22
0
8
0
50
0
8
0
0
% P
% Gln:
0
0
0
8
0
0
8
0
0
0
8
8
0
0
36
% Q
% Arg:
0
0
0
36
15
8
8
0
0
0
0
0
0
0
0
% R
% Ser:
8
29
15
8
0
0
0
22
8
58
8
22
8
0
0
% S
% Thr:
0
0
0
0
29
8
15
0
8
15
0
0
8
8
0
% T
% Val:
50
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
15
8
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _