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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1B
All Species:
16.06
Human Site:
S642
Identified Species:
27.18
UniProt:
Q9UPS6
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPS6
NP_055863.1
1923
208732
S642
S
G
E
D
M
E
I
S
D
D
E
M
P
S
A
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
A619
P
P
P
P
P
Y
L
A
S
L
P
L
G
Y
P
Rhesus Macaque
Macaca mulatta
XP_001092031
624
66545
Dog
Lupus familis
XP_543382
1925
209302
S644
S
G
E
D
M
E
I
S
D
D
E
M
P
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
S633
S
G
E
D
M
E
I
S
D
D
E
M
P
S
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510235
695
75024
Chicken
Gallus gallus
Q5F3P8
2008
223067
S642
S
G
E
D
M
E
I
S
D
D
E
M
N
S
A
Frog
Xenopus laevis
Q66J90
1938
216239
G652
V
I
P
I
L
P
P
G
F
P
P
L
P
P
P
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
P659
H
A
A
G
F
P
L
P
P
H
H
L
P
H
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
C575
S
E
N
K
K
R
S
C
E
K
N
N
K
V
L
Honey Bee
Apis mellifera
XP_395451
1406
159180
R341
K
T
L
D
L
D
T
R
I
A
M
L
L
K
D
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
R442
E
Q
V
H
I
K
E
R
T
A
V
I
R
G
K
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
S621
R
E
F
D
K
E
E
S
G
D
H
F
A
K
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
S248
D
E
D
D
A
P
P
S
D
P
R
L
A
H
G
Conservation
Percent
Protein Identity:
100
37.3
27.9
91.9
N.A.
87.7
N.A.
N.A.
23.1
61.5
55
51
N.A.
24.7
23.9
22.3
21.3
Protein Similarity:
100
50.3
28.8
93.9
N.A.
90.2
N.A.
N.A.
26.7
71.1
66.6
63.6
N.A.
39.4
38.6
35.2
35.2
P-Site Identity:
100
0
0
100
N.A.
100
N.A.
N.A.
0
93.3
6.6
6.6
N.A.
6.6
6.6
0
26.6
P-Site Similarity:
100
20
0
100
N.A.
100
N.A.
N.A.
0
93.3
20
20
N.A.
13.3
26.6
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
8
0
0
8
0
15
0
0
15
0
29
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
50
0
8
0
0
36
36
0
0
0
0
8
% D
% Glu:
8
22
29
0
0
36
15
0
8
0
29
0
0
0
0
% E
% Phe:
0
0
8
0
8
0
0
0
8
0
0
8
0
0
0
% F
% Gly:
0
29
0
8
0
0
0
8
8
0
0
0
8
8
8
% G
% His:
8
0
0
8
0
0
0
0
0
8
15
0
0
15
8
% H
% Ile:
0
8
0
8
8
0
29
0
8
0
0
8
0
0
0
% I
% Lys:
8
0
0
8
15
8
0
0
0
8
0
0
8
15
8
% K
% Leu:
0
0
8
0
15
0
15
0
0
8
0
36
8
0
8
% L
% Met:
0
0
0
0
29
0
0
0
0
0
8
29
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
8
8
8
0
0
% N
% Pro:
8
8
15
8
8
22
15
8
8
15
15
0
36
8
15
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
0
15
0
0
8
0
8
0
0
% R
% Ser:
36
0
0
0
0
0
8
43
8
0
0
0
0
29
0
% S
% Thr:
0
8
0
0
0
0
8
0
8
0
0
0
0
0
0
% T
% Val:
8
0
8
0
0
0
0
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _