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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1B
All Species:
13.33
Human Site:
S498
Identified Species:
22.56
UniProt:
Q9UPS6
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPS6
NP_055863.1
1923
208732
S498
G
P
E
K
P
H
D
S
L
D
S
R
I
E
M
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
S487
V
P
F
A
Q
H
S
S
L
D
S
R
I
E
M
Rhesus Macaque
Macaca mulatta
XP_001092031
624
66545
Dog
Lupus familis
XP_543382
1925
209302
S500
G
L
E
K
P
H
D
S
L
D
S
R
I
E
M
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
S489
G
P
E
K
P
H
D
S
L
D
S
R
I
E
M
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510235
695
75024
Chicken
Gallus gallus
Q5F3P8
2008
223067
P508
K
E
Q
R
T
K
L
P
F
L
N
E
H
D
S
Frog
Xenopus laevis
Q66J90
1938
216239
R508
Q
N
S
D
S
E
I
R
M
E
G
S
P
I
S
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
S524
M
D
G
S
P
I
S
S
S
S
S
Q
L
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
D444
E
N
I
K
T
W
S
D
R
R
A
W
T
A
F
Honey Bee
Apis mellifera
XP_395451
1406
159180
L210
G
K
V
L
K
V
F
L
D
A
F
G
E
E
C
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
P311
E
E
S
P
P
P
P
P
P
P
P
V
A
S
V
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
R486
D
D
D
R
G
S
K
R
Y
D
D
D
R
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
F117
T
S
T
S
S
S
I
F
S
S
S
T
R
Q
P
Conservation
Percent
Protein Identity:
100
37.3
27.9
91.9
N.A.
87.7
N.A.
N.A.
23.1
61.5
55
51
N.A.
24.7
23.9
22.3
21.3
Protein Similarity:
100
50.3
28.8
93.9
N.A.
90.2
N.A.
N.A.
26.7
71.1
66.6
63.6
N.A.
39.4
38.6
35.2
35.2
P-Site Identity:
100
66.6
0
93.3
N.A.
100
N.A.
N.A.
0
0
0
20
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
66.6
0
93.3
N.A.
100
N.A.
N.A.
0
26.6
13.3
33.3
N.A.
13.3
13.3
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
8
8
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
15
8
8
0
0
22
8
8
36
8
8
0
8
0
% D
% Glu:
15
15
22
0
0
8
0
0
0
8
0
8
8
36
0
% E
% Phe:
0
0
8
0
0
0
8
8
8
0
8
0
0
0
8
% F
% Gly:
29
0
8
0
8
0
0
0
0
0
8
8
0
8
0
% G
% His:
0
0
0
0
0
29
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
8
15
0
0
0
0
0
29
8
0
% I
% Lys:
8
8
0
29
8
8
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
8
0
0
8
8
29
8
0
0
8
0
0
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
29
% M
% Asn:
0
15
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
22
0
8
36
8
8
15
8
8
8
0
8
0
15
% P
% Gln:
8
0
8
0
8
0
0
0
0
0
0
8
0
8
0
% Q
% Arg:
0
0
0
15
0
0
0
15
8
8
0
29
15
0
0
% R
% Ser:
0
8
15
15
15
15
22
36
15
15
43
8
0
15
22
% S
% Thr:
8
0
8
0
15
0
0
0
0
0
0
8
8
0
0
% T
% Val:
8
0
8
0
0
8
0
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _