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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 10
Human Site: S1130 Identified Species: 16.92
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S1130 S S S E S S P S S S E D E E E
Chimpanzee Pan troglodytes XP_523492 1707 185692 V1003 T T K K E T G V S D G E D E E
Rhesus Macaque Macaca mulatta XP_001092031 624 66545
Dog Lupus familis XP_543382 1925 209302 S1138 S S S E S S S S S S E D E E E
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1172 E F E S S S E S E S S S S S S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 S11 P K H P G E K S P T P P H P S
Chicken Gallus gallus Q5F3P8 2008 223067 D1125 S S S D S D E D D D E E E E E
Frog Xenopus laevis Q66J90 1938 216239 E1074 S S S D S D D E I E E E D D D
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 V1056 E E E E E R I V G M D D E E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 N956 Q R T T T I R N R N L V G T M
Honey Bee Apis mellifera XP_395451 1406 159180 P722 K R P I T S L P S V S S S S S
Nematode Worm Caenorhab. elegans Q18221 1507 171664 S823 R Q E A E K P S N H L I A D M
Sea Urchin Strong. purpuratus XP_791552 1963 220543 T1076 S S L D E V P T N A Q M M Q M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 I629 T E H L L K T I R T K I T L P
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 20 0 93.3 N.A. 26.6 N.A. N.A. 6.6 53.3 33.3 26.6 N.A. 0 13.3 13.3 20
P-Site Similarity: 100 60 0 93.3 N.A. 26.6 N.A. N.A. 13.3 66.6 66.6 40 N.A. 26.6 20 26.6 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 0 0 8 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 22 0 15 8 8 8 15 8 22 15 15 15 % D
% Glu: 15 15 22 22 29 8 15 8 8 8 29 22 29 36 29 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 8 0 8 0 8 0 0 % G
% His: 0 0 15 0 0 0 0 0 0 8 0 0 8 0 0 % H
% Ile: 0 0 0 8 0 8 8 8 8 0 0 15 0 0 0 % I
% Lys: 8 8 8 8 0 15 8 0 0 0 8 0 0 0 0 % K
% Leu: 0 0 8 8 8 0 8 0 0 0 15 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 8 8 0 22 % M
% Asn: 0 0 0 0 0 0 0 8 15 8 0 0 0 0 0 % N
% Pro: 8 0 8 8 0 0 22 8 8 0 8 8 0 8 8 % P
% Gln: 8 8 0 0 0 0 0 0 0 0 8 0 0 8 0 % Q
% Arg: 8 15 0 0 0 8 8 0 15 0 0 0 0 0 0 % R
% Ser: 36 36 29 8 36 29 8 36 29 22 15 15 15 15 22 % S
% Thr: 15 8 8 8 15 8 8 8 0 15 0 0 8 8 0 % T
% Val: 0 0 0 0 0 8 0 15 0 8 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _