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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PHF8 All Species: 0.61
Human Site: S623 Identified Species: 1.21
UniProt: Q9UPP1 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPP1 NP_055922.1 1060 117864 S623 R V K S L S K S R R T K I A K
Chimpanzee Pan troglodytes XP_521077 902 100718 E506 D H E D E I P E T V R T V Q L
Rhesus Macaque Macaca mulatta XP_001109325 941 106786 W544 K R L E M C P W E E D I L S S
Dog Lupus familis XP_549017 1024 113801 A596 R A K L T K K A D K A R L M A
Cat Felis silvestris
Mouse Mus musculus Q80TJ7 1023 113535 K595 R R A K I A K K V D S A R L V
Rat Rattus norvegicus NP_001101723 1023 113534 D597 A K I A K K V D S A R L V A E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508529 1024 113352 K604 S S K A T A R K A A K A K L H
Chicken Gallus gallus XP_414324 1061 118324 K610 K W K Y K N S K P D S L L K M
Frog Xenopus laevis NP_001085579 419 48261 E23 D V S R F M I E C D I C K D W
Zebra Danio Brachydanio rerio XP_694899 1032 114204 S592 S A N G A G S S L Q Q F Q P H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394272 917 104227 K521 P L K L T L P K P I M Y P Y V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789776 951 107984 K555 N T T K N T T K N T T D S R N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 80.3 39.1 93.7 N.A. 91.5 91.7 N.A. 76.3 50.5 26.4 61.5 N.A. N.A. 35.6 N.A. 36.5
Protein Similarity: 100 80.5 55.4 95.2 N.A. 94.2 94.3 N.A. 83.5 67.1 33.2 72 N.A. N.A. 51.7 N.A. 54.3
P-Site Identity: 100 0 0 20 N.A. 13.3 6.6 N.A. 6.6 6.6 6.6 6.6 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 13.3 26.6 46.6 N.A. 33.3 26.6 N.A. 26.6 33.3 6.6 13.3 N.A. N.A. 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 17 9 17 9 17 0 9 9 17 9 17 0 17 9 % A
% Cys: 0 0 0 0 0 9 0 0 9 0 0 9 0 0 0 % C
% Asp: 17 0 0 9 0 0 0 9 9 25 9 9 0 9 0 % D
% Glu: 0 0 9 9 9 0 0 17 9 9 0 0 0 0 9 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 0 0 0 9 0 9 0 0 0 0 0 0 0 0 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 17 % H
% Ile: 0 0 9 0 9 9 9 0 0 9 9 9 9 0 0 % I
% Lys: 17 9 42 17 17 17 25 42 0 9 9 9 17 9 9 % K
% Leu: 0 9 9 17 9 9 0 0 9 0 0 17 25 17 9 % L
% Met: 0 0 0 0 9 9 0 0 0 0 9 0 0 9 9 % M
% Asn: 9 0 9 0 9 9 0 0 9 0 0 0 0 0 9 % N
% Pro: 9 0 0 0 0 0 25 0 17 0 0 0 9 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 9 0 9 9 0 % Q
% Arg: 25 17 0 9 0 0 9 0 9 9 17 9 9 9 0 % R
% Ser: 17 9 9 9 0 9 17 17 9 0 17 0 9 9 9 % S
% Thr: 0 9 9 0 25 9 9 0 9 9 17 9 0 0 0 % T
% Val: 0 17 0 0 0 0 9 0 9 9 0 0 17 0 17 % V
% Trp: 0 9 0 0 0 0 0 9 0 0 0 0 0 0 9 % W
% Tyr: 0 0 0 9 0 0 0 0 0 0 0 9 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _