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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTF2 All Species: 10.3
Human Site: S179 Identified Species: 18.89
UniProt: Q9UNY4 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNY4 NP_003585.3 1162 129588 S179 E M M E K D L S S G L V P K K
Chimpanzee Pan troglodytes XP_513683 1162 129565 S179 E T M E K D L S S G L V P K K
Rhesus Macaque Macaca mulatta XP_001112999 1163 129401 S179 E S M E K D L S S G L V P K K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q5NC05 1138 125512 A151 E E G E R K T A D K K L R E N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416595 1178 129334 K152 Q G S G E E S K A K G V E A E
Frog Xenopus laevis NP_001084942 1187 131668 K156 K K S D Q D T K A G A H G E I
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P34739 1061 118357 S123 E L E Q R A L S P S T R M S I
Honey Bee Apis mellifera XP_393754 954 109196 R37 E E N K N I E R K Q I F V I E
Nematode Worm Caenorhab. elegans NP_502137 1091 122548 A129 T P I S K K L A E S T D L R S
Sea Urchin Strong. purpuratus XP_787293 600 68137
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FIY7 1277 144314 E149 V E P E L L V E N L V V A K E
Baker's Yeast Sacchar. cerevisiae P31244 790 91412
Red Bread Mold Neurospora crassa Q7S1P9 1222 137173 A154 A F V G E K V A S D I L H V I
Conservation
Percent
Protein Identity: 100 99.1 95.8 N.A. N.A. 70.3 N.A. N.A. N.A. 53.5 51 N.A. N.A. 32.1 31.8 28.3 26.8
Protein Similarity: 100 99.4 96.9 N.A. N.A. 79.6 N.A. N.A. N.A. 66.2 66.8 N.A. N.A. 51.2 49.3 48.5 37.3
P-Site Identity: 100 93.3 93.3 N.A. N.A. 13.3 N.A. N.A. N.A. 6.6 13.3 N.A. N.A. 20 6.6 13.3 0
P-Site Similarity: 100 93.3 93.3 N.A. N.A. 40 N.A. N.A. N.A. 40 46.6 N.A. N.A. 40 26.6 33.3 0
Percent
Protein Identity: N.A. N.A. N.A. 23.1 21.3 21.3
Protein Similarity: N.A. N.A. N.A. 42.6 37.8 39.9
P-Site Identity: N.A. N.A. N.A. 20 0 6.6
P-Site Similarity: N.A. N.A. N.A. 46.6 0 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 8 0 24 16 0 8 0 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 31 0 0 8 8 0 8 0 0 0 % D
% Glu: 47 24 8 39 16 8 8 8 8 0 0 0 8 16 24 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 8 8 16 0 0 0 0 0 31 8 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % H
% Ile: 0 0 8 0 0 8 0 0 0 0 16 0 0 8 24 % I
% Lys: 8 8 0 8 31 24 0 16 8 16 8 0 0 31 24 % K
% Leu: 0 8 0 0 8 8 39 0 0 8 24 16 8 0 0 % L
% Met: 0 8 24 0 0 0 0 0 0 0 0 0 8 0 0 % M
% Asn: 0 0 8 0 8 0 0 0 8 0 0 0 0 0 8 % N
% Pro: 0 8 8 0 0 0 0 0 8 0 0 0 24 0 0 % P
% Gln: 8 0 0 8 8 0 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 16 0 0 8 0 0 0 8 8 8 0 % R
% Ser: 0 8 16 8 0 0 8 31 31 16 0 0 0 8 8 % S
% Thr: 8 8 0 0 0 0 16 0 0 0 16 0 0 0 0 % T
% Val: 8 0 8 0 0 0 16 0 0 0 8 39 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _