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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TIMELESS All Species: 34.24
Human Site: Y377 Identified Species: 75.33
UniProt: Q9UNS1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNS1 NP_003911.2 1208 138630 Y377 A Q Q H D E T Y Y M W A L A F
Chimpanzee Pan troglodytes XP_509535 1209 138911 Y377 A Q Q Y D E T Y Y M W A L A F
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538233 1446 163698 Y606 A Q Q H D E T Y Y M W A L A F
Cat Felis silvestris
Mouse Mus musculus Q9R1X4 1197 137484 Y377 A Q Q H D E T Y Y M W A M A F
Rat Rattus norvegicus Q9Z2Y1 1205 138547 Y377 A Q Q H D E T Y Y M W A M A F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512607 1213 138721 Y372 A Q Q H D E T Y Y L W A L A F
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922924 1278 147885 Y377 A Q Q H D E T Y Y M W A L T F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524341 1384 159345 Y374 S S S H D D S Y L L W A I R F
Honey Bee Apis mellifera XP_623203 520 60789
Nematode Worm Caenorhab. elegans NP_499594 1353 156992 L375 S Q I N Y F F L I K F V L R F
Sea Urchin Strong. purpuratus XP_784350 1529 176104 Y382 A Q E N D E S Y Y F W A M Q F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.6 N.A. 83.8 81.4 N.A. 70.2 N.A. N.A. 59.5 N.A. 33.1 20.3 23.2 38
Protein Similarity: 100 99.7 N.A. 77.9 N.A. 90.5 89.6 N.A. 80.4 N.A. N.A. 73.6 N.A. 53 30.7 43 55.7
P-Site Identity: 100 93.3 N.A. 100 N.A. 93.3 93.3 N.A. 93.3 N.A. N.A. 93.3 N.A. 40 0 20 60
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 100 N.A. N.A. 93.3 N.A. 73.3 0 40 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 73 0 0 0 0 0 0 0 0 0 0 82 0 55 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 82 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 0 0 73 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 10 10 0 0 10 10 0 0 0 91 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 64 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 10 10 19 0 0 55 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 55 0 0 28 0 0 % M
% Asn: 0 0 0 19 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 82 64 0 0 0 0 0 0 0 0 0 0 10 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 19 0 % R
% Ser: 19 10 10 0 0 0 19 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 64 0 0 0 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 82 0 0 0 0 % W
% Tyr: 0 0 0 10 10 0 0 82 73 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _