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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TIMELESS All Species: 19.39
Human Site: S552 Identified Species: 42.67
UniProt: Q9UNS1 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNS1 NP_003911.2 1208 138630 S552 V S G N V P S S P E E V E A V
Chimpanzee Pan troglodytes XP_509535 1209 138911 S552 V S G N V P S S P E E V E A V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_538233 1446 163698 S780 A S D H V P Y S A G E L E A V
Cat Felis silvestris
Mouse Mus musculus Q9R1X4 1197 137484 S548 Q G V A F S Q S P G E L E A M
Rat Rattus norvegicus Q9Z2Y1 1205 138547 S548 Q G V A F S R S P E E L Q A M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512607 1213 138721 S547 P A G T L P L S P E Q Q E E L
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922924 1278 147885 S545 K K P E M E T S A E D L E Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524341 1384 159345 A546 T K S K P P A A P Q P T E E E
Honey Bee Apis mellifera XP_623203 520 60789
Nematode Worm Caenorhab. elegans NP_499594 1353 156992 S551 R S E F D G M S K K D L D R L
Sea Urchin Strong. purpuratus XP_784350 1529 176104 N556 I S L F S L F N E E E N Q L T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 N.A. 73.6 N.A. 83.8 81.4 N.A. 70.2 N.A. N.A. 59.5 N.A. 33.1 20.3 23.2 38
Protein Similarity: 100 99.7 N.A. 77.9 N.A. 90.5 89.6 N.A. 80.4 N.A. N.A. 73.6 N.A. 53 30.7 43 55.7
P-Site Identity: 100 100 N.A. 53.3 N.A. 33.3 33.3 N.A. 40 N.A. N.A. 20 N.A. 20 0 13.3 20
P-Site Similarity: 100 100 N.A. 66.6 N.A. 46.6 53.3 N.A. 66.6 N.A. N.A. 46.6 N.A. 40 0 46.6 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 19 0 0 10 10 19 0 0 0 0 46 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 10 0 10 0 0 0 0 0 19 0 10 0 0 % D
% Glu: 0 0 10 10 0 10 0 0 10 55 55 0 64 19 10 % E
% Phe: 0 0 0 19 19 0 10 0 0 0 0 0 0 0 0 % F
% Gly: 0 19 28 0 0 10 0 0 0 19 0 0 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 19 0 10 0 0 0 0 10 10 0 0 0 0 0 % K
% Leu: 0 0 10 0 10 10 10 0 0 0 0 46 0 10 19 % L
% Met: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 19 % M
% Asn: 0 0 0 19 0 0 0 10 0 0 0 10 0 0 0 % N
% Pro: 10 0 10 0 10 46 0 0 55 0 10 0 0 0 0 % P
% Gln: 19 0 0 0 0 0 10 0 0 10 10 10 19 10 0 % Q
% Arg: 10 0 0 0 0 0 10 0 0 0 0 0 0 10 0 % R
% Ser: 0 46 10 0 10 19 19 73 0 0 0 0 0 0 10 % S
% Thr: 10 0 0 10 0 0 10 0 0 0 0 10 0 0 10 % T
% Val: 19 0 19 0 28 0 0 0 0 0 0 19 0 0 28 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _