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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLEKHH1 All Species: 11.21
Human Site: Y749 Identified Species: 30.83
UniProt: Q9ULM0 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9ULM0 NP_065766.1 1364 151232 Y749 S C D S D E D Y E A G G T R R
Chimpanzee Pan troglodytes XP_525888 1493 168136 D872 R S C D S D E D Y E A S G R S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537487 1476 163215 Y861 S C D S D E D Y E A G G S R R
Cat Felis silvestris
Mouse Mus musculus Q80TI1 1356 150890 Y743 S C D S D E D Y E A G G T G R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516496 937 103987 N368 T V A A G S T N V S V G S E F
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q00IB7 1433 160027 D812 R S C D S D E D Y E A G G R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W5D0 1820 198623 S1077 E H V S D S D S E E R E D A A
Honey Bee Apis mellifera XP_001120273 1571 174100 S876 E V E H V S D S D S E E R D A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782886 2057 229359 E997 Q S A V S D D E G D E K T E P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49 N.A. 80.5 N.A. 83.5 N.A. N.A. 43.1 N.A. N.A. 56.7 N.A. 30.7 35.6 N.A. 30.7
Protein Similarity: 100 65.5 N.A. 84.1 N.A. 88.8 N.A. N.A. 54.1 N.A. N.A. 71.8 N.A. 46.4 51.5 N.A. 43.4
P-Site Identity: 100 6.6 N.A. 93.3 N.A. 93.3 N.A. N.A. 6.6 N.A. N.A. 13.3 N.A. 26.6 6.6 N.A. 13.3
P-Site Similarity: 100 20 N.A. 100 N.A. 93.3 N.A. N.A. 33.3 N.A. N.A. 26.6 N.A. 26.6 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 23 12 0 0 0 0 0 34 23 0 0 12 23 % A
% Cys: 0 34 23 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 34 23 45 34 67 23 12 12 0 0 12 12 0 % D
% Glu: 23 0 12 0 0 34 23 12 45 34 23 23 0 23 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % F
% Gly: 0 0 0 0 12 0 0 0 12 0 34 56 23 12 12 % G
% His: 0 12 0 12 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % P
% Gln: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 23 0 0 0 0 0 0 0 0 0 12 0 12 45 34 % R
% Ser: 34 34 0 45 34 34 0 23 0 23 0 12 23 0 12 % S
% Thr: 12 0 0 0 0 0 12 0 0 0 0 0 34 0 0 % T
% Val: 0 23 12 12 12 0 0 0 12 0 12 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 34 23 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _