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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C1
All Species:
34.24
Human Site:
T249
Identified Species:
62.78
UniProt:
Q9UL18
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UL18
NP_036331.1
857
97214
T249
D
E
Q
P
K
P
L
T
D
S
Q
R
V
R
F
Chimpanzee
Pan troglodytes
XP_001167349
817
92830
V227
I
K
G
L
K
V
E
V
T
H
C
G
Q
M
K
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
T443
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Dog
Lupus familis
XP_532563
1037
115859
T429
D
E
Q
P
K
P
L
T
D
S
Q
R
V
R
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJG1
857
97083
T249
D
E
Q
P
K
P
L
T
D
S
Q
R
V
R
F
Rat
Rattus norvegicus
Q9QZ81
860
97300
T252
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510209
1055
118422
P447
D
P
F
P
R
P
G
P
Q
T
L
S
S
R
E
Chicken
Gallus gallus
Q5ZLG4
860
97253
T252
D
E
Q
P
R
P
L
T
D
S
H
R
V
K
F
Frog
Xenopus laevis
Q6DCX2
862
97626
T254
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
T252
D
E
Q
P
R
P
L
T
D
S
H
R
V
K
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
T620
L
K
A
K
I
N
N
T
T
N
L
D
Y
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
Q389
D
T
L
S
R
D
T
Q
L
S
S
F
E
T
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
S407
D
I
S
S
R
P
L
S
D
A
D
R
V
K
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
66.8
82.6
N.A.
99.5
82.3
N.A.
75.2
84.5
82
84.7
N.A.
23.2
N.A.
32.6
N.A.
Protein Similarity:
100
94.1
74.8
82.6
N.A.
99.7
91.2
N.A.
76.7
91.6
90.5
92
N.A.
37.1
N.A.
51.1
N.A.
P-Site Identity:
100
6.6
80
100
N.A.
100
80
N.A.
26.6
80
80
80
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
13.3
93.3
100
N.A.
100
93.3
N.A.
40
93.3
93.3
93.3
N.A.
20
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
62
0
0
0
0
8
0
0
70
0
8
8
0
0
0
% D
% Glu:
24
62
0
0
0
0
8
0
0
0
0
0
8
0
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
62
% F
% Gly:
0
0
8
0
0
0
8
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
16
0
0
0
0
% H
% Ile:
8
8
0
0
8
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
16
0
8
54
0
0
0
0
0
0
0
0
47
8
% K
% Leu:
8
0
8
8
0
0
70
0
8
0
16
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
8
0
0
8
0
0
0
0
0
% N
% Pro:
0
8
0
47
0
77
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
62
24
0
0
0
8
8
0
47
0
8
0
0
% Q
% Arg:
0
0
0
0
39
0
0
0
0
0
0
70
0
31
16
% R
% Ser:
0
0
8
16
0
0
0
8
0
70
8
8
8
8
0
% S
% Thr:
0
8
0
0
0
0
8
70
16
8
0
0
0
8
0
% T
% Val:
0
0
0
0
0
8
0
8
0
0
0
0
70
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _