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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C1
All Species:
31.82
Human Site:
S378
Identified Species:
58.33
UniProt:
Q9UL18
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UL18
NP_036331.1
857
97214
S378
P
D
R
Q
E
E
I
S
R
L
M
K
N
A
S
Chimpanzee
Pan troglodytes
XP_001167349
817
92830
I352
S
Y
N
L
D
P
Y
I
Q
E
F
G
I
K
V
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
L574
R
Q
E
E
I
S
K
L
V
S
M
R
S
A
S
Dog
Lupus familis
XP_532563
1037
115859
S558
P
D
R
Q
E
E
I
S
R
L
M
K
N
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJG1
857
97083
S378
P
D
R
Q
E
E
I
S
R
L
M
K
N
A
S
Rat
Rattus norvegicus
Q9QZ81
860
97300
S381
P
D
R
Q
E
E
I
S
K
L
M
R
S
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510209
1055
118422
S576
P
D
R
Q
E
E
I
S
R
L
M
K
N
A
S
Chicken
Gallus gallus
Q5ZLG4
860
97253
S381
P
D
R
Q
E
E
I
S
R
L
V
R
S
A
N
Frog
Xenopus laevis
Q6DCX2
862
97626
S383
P
D
R
Q
E
E
I
S
K
L
M
R
S
A
S
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
S381
P
D
R
Q
E
E
I
S
R
L
V
R
S
A
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
M749
N
V
R
K
R
K
I
M
N
L
L
Q
Y
F
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
K518
T
Q
R
E
D
R
I
K
Q
L
A
A
Q
A
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
L533
I
D
R
E
K
D
I
L
Q
T
V
Q
L
N
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
66.8
82.6
N.A.
99.5
82.3
N.A.
75.2
84.5
82
84.7
N.A.
23.2
N.A.
32.6
N.A.
Protein Similarity:
100
94.1
74.8
82.6
N.A.
99.7
91.2
N.A.
76.7
91.6
90.5
92
N.A.
37.1
N.A.
51.1
N.A.
P-Site Identity:
100
0
20
100
N.A.
100
80
N.A.
100
73.3
80
73.3
N.A.
20
N.A.
33.3
N.A.
P-Site Similarity:
100
13.3
40
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
46.6
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
8
8
0
77
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
70
0
0
16
8
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
8
24
62
62
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
85
8
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
8
8
8
8
8
16
0
0
31
0
8
0
% K
% Leu:
0
0
0
8
0
0
0
16
0
77
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
0
54
0
0
0
0
% M
% Asn:
8
0
8
0
0
0
0
0
8
0
0
0
31
8
16
% N
% Pro:
62
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
0
62
0
0
0
0
24
0
0
16
8
0
8
% Q
% Arg:
8
0
85
0
8
8
0
0
47
0
0
39
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
62
0
8
0
0
39
0
62
% S
% Thr:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
24
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _