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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2C1 All Species: 40
Human Site: S178 Identified Species: 73.33
UniProt: Q9UL18 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UL18 NP_036331.1 857 97214 S178 R Y T P V G R S F F S P P E G
Chimpanzee Pan troglodytes XP_001167349 817 92830 M168 H Q S V R P A M W K M M L N I
Rhesus Macaque Macaca mulatta XP_001100725 1053 117937 S372 R Y T P V G R S F F T A S E G
Dog Lupus familis XP_532563 1037 115859 S358 R Y T P V G R S F F S P P E G
Cat Felis silvestris
Mouse Mus musculus Q8CJG1 857 97083 S178 R Y T P V G R S F F S P P E G
Rat Rattus norvegicus Q9QZ81 860 97300 S181 R Y T P V G R S F F T A S E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510209 1055 118422 S374 R Y T P V G R S F F S P P E G
Chicken Gallus gallus Q5ZLG4 860 97253 S181 K Y T P V G R S F F S A P E G
Frog Xenopus laevis Q6DCX2 862 97626 S183 R Y T P V G R S F F T A S E G
Zebra Danio Brachydanio rerio A3KPK0 860 97313 S181 R Y T P V G R S F F S S P E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VUQ5 1214 136831 S554 K A I R V G R S F F K M S D P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34681 1040 115397 N250 P L L K N S A N F Y T W K S S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04379 1048 116172 S339 R Y I P V G R S F Y S P D I G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.3 66.8 82.6 N.A. 99.5 82.3 N.A. 75.2 84.5 82 84.7 N.A. 23.2 N.A. 32.6 N.A.
Protein Similarity: 100 94.1 74.8 82.6 N.A. 99.7 91.2 N.A. 76.7 91.6 90.5 92 N.A. 37.1 N.A. 51.1 N.A.
P-Site Identity: 100 0 80 100 N.A. 100 80 N.A. 100 86.6 80 93.3 N.A. 40 N.A. 6.6 N.A.
P-Site Similarity: 100 13.3 86.6 100 N.A. 100 86.6 N.A. 100 93.3 86.6 93.3 N.A. 53.3 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 37.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 52.3 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 73.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 80 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 16 0 0 0 0 31 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 70 0 % E
% Phe: 0 0 0 0 0 0 0 0 93 77 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 85 0 0 0 0 0 0 0 0 77 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 16 0 0 0 0 0 0 0 0 0 0 8 8 % I
% Lys: 16 0 0 8 0 0 0 0 0 8 8 0 8 0 0 % K
% Leu: 0 8 8 0 0 0 0 0 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 8 0 0 8 16 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 8 0 0 0 0 0 8 0 % N
% Pro: 8 0 0 77 0 8 0 0 0 0 0 39 47 0 8 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 70 0 0 8 8 0 85 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 0 0 8 0 85 0 0 54 8 31 8 8 % S
% Thr: 0 0 70 0 0 0 0 0 0 0 31 0 0 0 0 % T
% Val: 0 0 0 8 85 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % W
% Tyr: 0 77 0 0 0 0 0 0 0 16 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _