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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
13.33
Human Site:
S640
Identified Species:
26.67
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S640
L
N
R
D
I
A
D
S
Q
P
M
S
A
P
V
Chimpanzee
Pan troglodytes
XP_512758
709
71738
A573
P
E
G
G
L
P
V
A
P
S
P
A
L
P
E
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
S639
L
N
H
D
I
A
D
S
Q
P
M
S
A
P
V
Dog
Lupus familis
XP_547842
785
83131
S644
L
N
P
D
L
A
D
S
Q
P
M
S
A
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
S634
L
N
P
D
L
A
E
S
Q
P
V
S
A
P
V
Rat
Rattus norvegicus
NP_001100209
705
75711
A569
A
E
S
Q
P
V
S
A
P
V
A
S
K
C
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
T374
P
E
G
Q
A
V
S
T
P
V
T
S
T
S
T
Chicken
Gallus gallus
O93307
246
27619
V110
R
G
R
P
L
G
P
V
D
K
Y
R
V
R
K
Frog
Xenopus laevis
NP_001089925
276
31231
L139
K
E
K
S
R
G
V
L
R
E
W
Y
T
H
N
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
Q459
K
V
V
L
P
S
L
Q
L
T
V
S
S
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
D280
D
R
A
A
E
H
K
D
G
S
T
D
K
Q
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
M429
L
A
T
M
S
M
I
M
N
P
A
L
L
S
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
6.6
93.3
86.6
N.A.
73.3
6.6
N.A.
6.6
6.6
0
6.6
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
26.6
93.3
93.3
N.A.
93.3
13.3
N.A.
13.3
13.3
13.3
26.6
N.A.
0
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
9
9
9
34
0
17
0
0
17
9
34
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
0
0
34
0
0
25
9
9
0
0
9
0
0
0
% D
% Glu:
0
34
0
0
9
0
9
0
0
9
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
17
9
0
17
0
0
9
0
0
0
0
0
0
% G
% His:
0
0
9
0
0
9
0
0
0
0
0
0
0
9
9
% H
% Ile:
0
0
0
0
17
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
17
0
9
0
0
0
9
0
0
9
0
0
17
0
9
% K
% Leu:
42
0
0
9
34
0
9
9
9
0
0
9
17
0
0
% L
% Met:
0
0
0
9
0
9
0
9
0
0
25
0
0
0
0
% M
% Asn:
0
34
0
0
0
0
0
0
9
0
0
0
0
0
17
% N
% Pro:
17
0
17
9
17
9
9
0
25
42
9
0
0
42
9
% P
% Gln:
0
0
0
17
0
0
0
9
34
0
0
0
0
9
0
% Q
% Arg:
9
9
17
0
9
0
0
0
9
0
0
9
0
9
0
% R
% Ser:
0
0
9
9
9
9
17
34
0
17
0
59
9
25
0
% S
% Thr:
0
0
9
0
0
0
0
9
0
9
17
0
17
0
17
% T
% Val:
0
9
9
0
0
17
17
9
0
17
17
0
9
0
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _