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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
1.52
Human Site:
S625
Identified Species:
3.03
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S625
H
N
F
S
L
S
P
S
T
L
L
N
P
T
E
Chimpanzee
Pan troglodytes
XP_512758
709
71738
K558
P
G
L
A
L
P
L
K
P
E
T
A
I
S
V
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
P624
H
N
F
S
L
S
P
P
T
L
L
N
P
T
E
Dog
Lupus familis
XP_547842
785
83131
P629
H
N
F
P
L
T
P
P
T
L
L
N
P
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
P619
H
G
F
S
L
T
P
P
T
L
L
N
P
T
E
Rat
Rattus norvegicus
NP_001100209
705
75711
P554
T
P
S
T
L
L
N
P
A
E
L
N
P
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
P359
A
P
P
T
L
L
T
P
T
E
L
T
L
D
L
Chicken
Gallus gallus
O93307
246
27619
H95
Q
A
L
W
L
E
A
H
Y
Q
E
A
E
K
L
Frog
Xenopus laevis
NP_001089925
276
31231
G124
L
P
R
T
I
W
D
G
E
E
T
S
Y
C
F
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
Y444
N
G
L
Q
I
D
S
Y
S
L
V
T
E
G
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
W265
T
T
T
Q
V
S
N
W
F
K
N
R
R
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
I414
L
A
S
S
K
G
D
I
N
M
N
H
A
A
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
6.6
93.3
80
N.A.
80
26.6
N.A.
20
6.6
0
6.6
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
20
93.3
86.6
N.A.
86.6
33.3
N.A.
26.6
6.6
20
33.3
N.A.
13.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
17
0
9
0
0
9
0
9
0
0
17
9
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
0
0
9
17
0
0
0
0
0
0
17
0
% D
% Glu:
0
0
0
0
0
9
0
0
9
34
9
0
17
0
34
% E
% Phe:
0
0
34
0
0
0
0
0
9
0
0
0
0
0
9
% F
% Gly:
0
25
0
0
0
9
0
9
0
0
0
0
0
9
0
% G
% His:
34
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
17
0
0
9
0
0
0
0
9
0
0
% I
% Lys:
0
0
0
0
9
0
0
9
0
9
0
0
0
9
0
% K
% Leu:
17
0
25
0
67
17
9
0
0
42
50
0
9
0
25
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
9
25
0
0
0
0
17
0
9
0
17
42
0
0
9
% N
% Pro:
9
25
9
9
0
9
34
42
9
0
0
0
42
0
0
% P
% Gln:
9
0
0
17
0
0
0
0
0
9
0
0
0
9
9
% Q
% Arg:
0
0
9
0
0
0
0
0
0
0
0
9
9
0
9
% R
% Ser:
0
0
17
34
0
25
9
9
9
0
0
9
0
9
0
% S
% Thr:
17
9
9
25
0
17
9
0
42
0
17
17
0
34
0
% T
% Val:
0
0
0
0
9
0
0
0
0
0
9
0
0
0
9
% V
% Trp:
0
0
0
9
0
9
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _