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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
10.61
Human Site:
S595
Identified Species:
21.21
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S595
A
Q
V
N
A
N
L
S
S
E
N
I
S
G
S
Chimpanzee
Pan troglodytes
XP_512758
709
71738
Q528
V
T
G
V
A
V
Q
Q
G
K
I
I
L
T
A
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
S594
A
Q
V
N
A
N
L
S
S
E
N
I
S
G
S
Dog
Lupus familis
XP_547842
785
83131
L599
N
A
Q
I
N
A
N
L
S
S
E
N
I
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
S589
A
Q
V
N
A
S
L
S
S
E
N
L
S
G
S
Rat
Rattus norvegicus
NP_001100209
705
75711
S524
N
L
S
S
E
N
L
S
G
S
G
L
H
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
A329
S
M
T
P
E
T
I
A
G
P
S
L
H
P
M
Chicken
Gallus gallus
O93307
246
27619
G65
A
I
V
A
F
H
T
G
N
Y
R
E
L
Y
H
Frog
Xenopus laevis
NP_001089925
276
31231
E94
W
L
K
A
H
Y
V
E
A
E
K
L
R
G
R
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
L414
V
E
V
K
E
E
D
L
R
K
D
V
S
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
D235
K
S
R
S
V
L
R
D
W
Y
S
H
N
P
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
D384
P
D
L
A
N
L
T
D
A
T
G
L
Q
A
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
13.3
100
6.6
N.A.
86.6
20
N.A.
0
13.3
13.3
13.3
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
26.6
100
6.6
N.A.
100
33.3
N.A.
33.3
26.6
33.3
40
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
9
0
25
34
9
0
9
17
0
0
0
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
0
9
17
0
0
9
0
0
0
0
% D
% Glu:
0
9
0
0
25
9
0
9
0
34
9
9
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
9
0
0
0
0
9
25
0
17
0
0
34
9
% G
% His:
0
0
0
0
9
9
0
0
0
0
0
9
17
0
9
% H
% Ile:
0
9
0
9
0
0
9
0
0
0
9
25
9
0
0
% I
% Lys:
9
0
9
9
0
0
0
0
0
17
9
0
0
0
0
% K
% Leu:
0
17
9
0
0
17
34
17
0
0
0
42
17
0
9
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
17
0
0
25
17
25
9
0
9
0
25
9
9
0
0
% N
% Pro:
9
0
0
9
0
0
0
0
0
9
0
0
0
25
0
% P
% Gln:
0
25
9
0
0
0
9
9
0
0
0
0
9
0
9
% Q
% Arg:
0
0
9
0
0
0
9
0
9
0
9
0
9
0
9
% R
% Ser:
9
9
9
17
0
9
0
34
34
17
17
0
34
9
25
% S
% Thr:
0
9
9
0
0
9
17
0
0
9
0
0
0
9
0
% T
% Val:
17
0
42
9
9
9
9
0
0
0
0
9
0
9
0
% V
% Trp:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
9
0
0
0
17
0
0
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _