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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
10.3
Human Site:
S315
Identified Species:
20.61
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S315
S
P
H
P
L
S
S
S
S
D
G
I
T
N
L
Chimpanzee
Pan troglodytes
XP_512758
709
71738
E249
G
N
P
T
T
E
D
E
S
S
R
S
P
E
D
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
S314
S
P
H
P
L
S
S
S
S
D
G
I
T
N
L
Dog
Lupus familis
XP_547842
785
83131
S319
S
P
H
P
L
S
G
S
S
D
S
V
T
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
A308
S
P
H
P
L
S
G
A
S
D
G
V
T
N
L
Rat
Rattus norvegicus
NP_001100209
705
75711
L245
A
S
D
G
V
T
N
L
S
L
S
S
H
M
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
S50
N
S
S
D
G
I
T
S
L
T
L
S
S
H
M
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
NP_001089925
276
31231
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
R135
L
V
A
F
H
Q
A
R
Y
Q
E
L
Y
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
E105
Q
Q
V
V
C
V
C
E
A
L
R
Q
E
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
6.6
100
80
N.A.
80
6.6
N.A.
6.6
0
0
0
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
6.6
100
86.6
N.A.
93.3
33.3
N.A.
40
0
0
26.6
N.A.
0
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
0
9
9
9
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
9
0
9
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
9
0
0
9
0
0
34
0
0
0
0
9
% D
% Glu:
0
0
0
0
0
9
0
17
0
0
9
0
9
9
9
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
9
9
0
17
0
0
0
25
0
0
9
0
% G
% His:
0
0
34
0
9
0
0
0
0
0
0
0
9
9
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
0
0
17
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
9
0
0
0
34
0
0
9
9
17
9
9
0
0
34
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% M
% Asn:
9
9
0
0
0
0
9
0
0
0
0
0
0
34
9
% N
% Pro:
0
34
9
34
0
0
0
0
0
0
0
0
9
0
0
% P
% Gln:
9
9
0
0
0
9
0
0
0
9
0
9
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
9
0
0
17
0
0
0
0
% R
% Ser:
34
17
9
0
0
34
17
34
50
9
17
25
9
9
0
% S
% Thr:
0
0
0
9
9
9
9
0
0
9
0
0
34
0
0
% T
% Val:
0
9
9
9
9
9
0
0
0
0
0
17
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _