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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIX4
All Species:
13.64
Human Site:
S249
Identified Species:
27.27
UniProt:
Q9UIU6
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIU6
NP_059116.3
781
82933
S249
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
H
L
Chimpanzee
Pan troglodytes
XP_512758
709
71738
R183
Y
C
F
K
E
R
S
R
A
A
L
K
A
C
Y
Rhesus Macaque
Macaca mulatta
XP_001096689
780
82997
S248
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
H
L
Dog
Lupus familis
XP_547842
785
83131
S253
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61321
775
82244
S242
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
H
L
Rat
Rattus norvegicus
NP_001100209
705
75711
L179
S
P
A
E
K
R
H
L
A
K
I
T
G
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517242
510
52692
Chicken
Gallus gallus
O93307
246
27619
Frog
Xenopus laevis
NP_001089925
276
31231
Zebra Danio
Brachydanio rerio
NP_571793
595
64668
A69
P
T
M
D
S
L
F
A
H
S
S
P
A
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27350
416
45006
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781616
565
61026
D39
G
D
T
S
S
T
T
D
S
N
A
G
I
S
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.2
97.8
91.5
N.A.
90.6
82.5
N.A.
46.6
20.3
25.7
40.4
N.A.
26.8
N.A.
N.A.
29
Protein Similarity:
100
45.4
98
95
N.A.
94.2
85.9
N.A.
53.2
25.8
29.3
52.6
N.A.
33.9
N.A.
N.A.
44.5
P-Site Identity:
100
20
100
100
N.A.
100
0
N.A.
0
0
0
0
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
20
100
100
N.A.
100
6.6
N.A.
0
0
0
20
N.A.
0
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
9
17
42
9
0
17
0
0
% A
% Cys:
0
9
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
0
9
0
9
0
0
0
9
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
9
9
0
0
0
0
0
34
0
0
0
0
% E
% Phe:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
9
9
0
0
% G
% His:
0
0
0
0
0
0
9
0
9
0
0
0
0
34
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
0
9
0
0
% I
% Lys:
0
34
0
9
9
0
0
0
0
9
0
42
0
0
0
% K
% Leu:
0
0
0
0
0
9
0
9
0
0
9
0
0
9
42
% L
% Met:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
34
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
9
9
0
0
0
0
34
0
34
0
0
9
0
0
0
% P
% Gln:
0
0
34
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
34
17
0
9
0
0
0
0
34
0
0
% R
% Ser:
9
0
0
9
17
0
9
34
9
9
9
0
0
9
9
% S
% Thr:
0
9
9
0
0
9
9
0
0
0
0
9
0
0
9
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
42
0
0
0
0
34
0
0
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _