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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MUTYH
All Species:
15.76
Human Site:
S317
Identified Species:
31.52
UniProt:
Q9UIF7
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UIF7
NP_001041636.1
546
60069
S317
E
Q
E
Q
L
L
A
S
G
S
L
S
G
S
P
Chimpanzee
Pan troglodytes
XP_001155767
546
60211
S317
E
R
E
Q
L
L
A
S
R
S
L
S
G
S
P
Rhesus Macaque
Macaca mulatta
XP_001101469
533
58769
S303
E
R
E
Q
L
L
A
S
R
S
L
S
G
N
P
Dog
Lupus familis
XP_539632
573
63255
S343
E
R
G
K
L
L
A
S
Q
S
L
P
G
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q99P21
515
57711
L288
Q
R
V
E
R
G
Q
L
S
A
L
P
G
R
P
Rat
Rattus norvegicus
Q8R5G2
516
57901
L288
Q
R
V
G
Q
G
R
L
S
A
L
P
G
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519000
605
64943
S319
E
T
S
E
L
L
S
S
R
S
L
R
A
S
R
Chicken
Gallus gallus
XP_422433
511
56150
K284
E
L
A
S
A
S
Q
K
L
F
G
K
T
T
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_686698
526
59141
K289
D
C
K
R
L
L
N
K
L
A
T
N
P
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791369
425
47583
T212
R
D
L
A
T
K
L
T
K
S
N
G
Q
S
L
Poplar Tree
Populus trichocarpa
XP_002321221
480
54779
C267
S
C
P
V
S
G
Q
C
R
A
L
T
I
S
K
Maize
Zea mays
NP_001150481
469
52213
C256
T
K
P
G
C
S
Q
C
P
V
S
S
H
C
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
92.8
76.7
N.A.
73.4
73
N.A.
54.7
55.3
N.A.
46.1
N.A.
N.A.
N.A.
N.A.
37.1
Protein Similarity:
100
99.6
94.6
83.4
N.A.
81.1
80.7
N.A.
64.9
67.2
N.A.
60.2
N.A.
N.A.
N.A.
N.A.
49.4
P-Site Identity:
100
86.6
80
66.6
N.A.
20
26.6
N.A.
46.6
6.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
93.3
93.3
80
N.A.
46.6
46.6
N.A.
60
13.3
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
33.7
32.4
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
49.6
48.9
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
9
0
34
0
0
34
0
0
9
0
0
% A
% Cys:
0
17
0
0
9
0
0
17
0
0
0
0
0
9
0
% C
% Asp:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
50
0
25
17
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
9
17
0
25
0
0
9
0
9
9
50
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
9
9
9
0
9
0
17
9
0
0
9
0
9
9
% K
% Leu:
0
9
9
0
50
50
9
17
17
0
67
0
0
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
9
9
0
9
9
% N
% Pro:
0
0
17
0
0
0
0
0
9
0
0
25
9
0
50
% P
% Gln:
17
9
0
25
9
0
34
0
9
0
0
0
9
0
9
% Q
% Arg:
9
42
0
9
9
0
9
0
34
0
0
9
0
9
9
% R
% Ser:
9
0
9
9
9
17
9
42
17
50
9
34
0
59
0
% S
% Thr:
9
9
0
0
9
0
0
9
0
0
9
9
9
9
0
% T
% Val:
0
0
17
9
0
0
0
0
0
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _