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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1L1
All Species:
15.45
Human Site:
S658
Identified Species:
42.5
UniProt:
Q9UHC9
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC9
NP_001095118.1
1359
148698
S658
L
G
S
Y
S
S
W
S
R
V
M
V
D
S
K
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
I630
T
V
V
I
S
Y
A
I
M
F
L
Y
I
S
L
Rhesus Macaque
Macaca mulatta
NP_001071157
1332
145570
S658
L
G
S
Y
S
S
W
S
R
V
M
V
D
S
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q6T3U4
1333
147113
S658
L
G
S
Y
S
R
W
S
R
V
A
V
D
S
K
Rat
Rattus norvegicus
Q6T3U3
1331
146397
S658
L
G
S
Y
S
R
C
S
R
V
A
V
E
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624752
1358
152373
S640
L
G
Q
I
K
N
C
S
R
L
L
I
D
S
K
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
E653
L
G
R
Y
F
V
C
E
N
Q
L
W
S
I
L
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
R686
L
G
Q
F
N
G
C
R
R
L
M
I
D
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
E536
L
L
D
L
K
V
P
E
G
L
R
I
S
F
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39.3
93.8
N.A.
N.A.
75.9
76.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
25.8
39.8
Protein Similarity:
100
56.8
95.3
N.A.
N.A.
85
85.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
57.6
46.7
58.6
P-Site Identity:
100
13.3
100
N.A.
N.A.
86.6
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
20
46.6
P-Site Similarity:
100
20
100
N.A.
N.A.
86.6
80
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
73.3
26.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
12
0
0
0
23
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
45
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
0
0
0
0
0
0
0
0
0
56
0
0
% D
% Glu:
0
0
0
0
0
0
0
23
0
0
0
0
12
0
0
% E
% Phe:
0
0
0
12
12
0
0
0
0
12
0
0
0
12
0
% F
% Gly:
0
78
0
0
0
12
0
0
12
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
23
0
0
0
12
0
0
0
34
12
12
0
% I
% Lys:
0
0
0
0
23
0
0
0
0
0
0
0
0
0
67
% K
% Leu:
89
12
0
12
0
0
0
0
0
34
34
0
0
0
23
% L
% Met:
0
0
0
0
0
0
0
0
12
0
34
0
0
0
0
% M
% Asn:
0
0
0
0
12
12
0
0
12
0
0
0
0
0
12
% N
% Pro:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
23
0
0
0
0
0
0
12
0
0
0
0
0
% Q
% Arg:
0
0
12
0
0
23
0
12
67
0
12
0
0
0
0
% R
% Ser:
0
0
45
0
56
23
0
56
0
0
0
0
23
78
0
% S
% Thr:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
12
12
0
0
23
0
0
0
45
0
45
0
0
0
% V
% Trp:
0
0
0
0
0
0
34
0
0
0
0
12
0
0
0
% W
% Tyr:
0
0
0
56
0
12
0
0
0
0
0
12
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _