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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NPC1L1
All Species:
17.27
Human Site:
S466
Identified Species:
47.5
UniProt:
Q9UHC9
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHC9
NP_001095118.1
1359
148698
S466
P
E
A
Q
R
N
I
S
L
Q
D
I
C
Y
A
Chimpanzee
Pan troglodytes
XP_001155285
1277
141871
S457
I
E
N
I
T
A
S
S
N
N
E
T
V
T
L
Rhesus Macaque
Macaca mulatta
NP_001071157
1332
145570
S466
P
E
A
Q
R
N
I
S
L
Q
H
I
C
Y
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q6T3U4
1333
147113
S466
H
E
A
Q
R
N
I
S
L
Q
D
I
C
Y
A
Rat
Rattus norvegicus
Q6T3U3
1331
146397
S466
P
E
A
E
R
N
I
S
L
Q
D
I
C
Y
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624752
1358
152373
T449
I
T
T
P
N
N
Y
T
L
A
N
I
C
F
A
Nematode Worm
Caenorhab. elegans
Q19127
1383
155438
C464
T
I
T
L
D
D
V
C
Y
R
P
M
G
P
G
Sea Urchin
Strong. purpuratus
XP_780036
1332
147422
D497
L
K
V
P
F
G
N
D
S
F
V
T
L
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12200
1170
132626
T364
F
Q
Y
A
T
L
E
T
D
P
I
N
L
W
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
39.3
93.8
N.A.
N.A.
75.9
76.5
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
25.8
39.8
Protein Similarity:
100
56.8
95.3
N.A.
N.A.
85
85.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
57.6
46.7
58.6
P-Site Identity:
100
13.3
93.3
N.A.
N.A.
93.3
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
33.3
0
0
P-Site Similarity:
100
20
93.3
N.A.
N.A.
93.3
100
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
53.3
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
45
12
0
12
0
0
0
12
0
0
0
0
56
% A
% Cys:
0
0
0
0
0
0
0
12
0
0
0
0
56
0
0
% C
% Asp:
0
0
0
0
12
12
0
12
12
0
34
0
0
0
12
% D
% Glu:
0
56
0
12
0
0
12
0
0
0
12
0
0
0
0
% E
% Phe:
12
0
0
0
12
0
0
0
0
12
0
0
0
12
0
% F
% Gly:
0
0
0
0
0
12
0
0
0
0
0
0
12
0
12
% G
% His:
12
0
0
0
0
0
0
0
0
0
12
0
0
12
0
% H
% Ile:
23
12
0
12
0
0
45
0
0
0
12
56
0
0
0
% I
% Lys:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
12
0
0
12
0
12
0
0
56
0
0
0
23
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
12
0
12
56
12
0
12
12
12
12
0
0
0
% N
% Pro:
34
0
0
23
0
0
0
0
0
12
12
0
0
12
0
% P
% Gln:
0
12
0
34
0
0
0
0
0
45
0
0
0
0
0
% Q
% Arg:
0
0
0
0
45
0
0
0
0
12
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
12
56
12
0
0
0
0
0
0
% S
% Thr:
12
12
23
0
23
0
0
23
0
0
0
23
0
12
0
% T
% Val:
0
0
12
0
0
0
12
0
0
0
12
0
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% W
% Tyr:
0
0
12
0
0
0
12
0
12
0
0
0
0
45
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _