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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AFF4
All Species:
18.79
Human Site:
S540
Identified Species:
51.67
UniProt:
Q9UHB7
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UHB7
NP_055238.1
1163
127459
S540
S
K
T
I
Q
K
G
S
E
S
G
R
G
R
Q
Chimpanzee
Pan troglodytes
Q7YQM2
1272
140491
I565
R
P
R
P
T
Q
K
I
P
E
T
K
A
L
K
Rhesus Macaque
Macaca mulatta
XP_001106070
1162
127341
S540
S
K
T
I
Q
K
G
S
E
S
G
R
G
R
Q
Dog
Lupus familis
XP_850309
1163
127349
S540
S
K
T
V
Q
K
G
S
E
S
G
R
G
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9ESC8
1160
126621
S535
S
K
T
I
Q
K
G
S
E
S
G
R
G
R
Q
Rat
Rattus norvegicus
NP_001100471
1150
125665
S536
S
G
R
G
R
Q
K
S
P
A
Q
S
D
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515909
1378
146836
K732
T
E
G
H
A
Q
G
K
S
R
G
Q
K
S
P
Chicken
Gallus gallus
XP_414653
1160
127039
S540
S
K
P
T
Q
K
G
S
E
S
S
R
G
R
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_684327
1030
113378
R425
T
K
Y
K
K
E
G
R
D
T
S
S
S
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
34.7
97.1
96.6
N.A.
93.3
92.6
N.A.
33.4
86.9
N.A.
57.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
50.7
98.1
98.4
N.A.
96.3
96
N.A.
49.9
92.7
N.A.
69.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
93.3
N.A.
100
13.3
N.A.
13.3
80
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
33.3
N.A.
40
80
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
0
0
0
12
0
0
12
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
12
0
0
0
12
0
0
% D
% Glu:
0
12
0
0
0
12
0
0
56
12
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
12
12
12
0
0
78
0
0
0
56
0
56
0
0
% G
% His:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
34
0
0
0
12
0
0
0
0
0
0
0
% I
% Lys:
0
67
0
12
12
56
23
12
0
0
0
12
12
0
12
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
12
12
12
0
0
0
0
23
0
0
0
0
0
12
% P
% Gln:
0
0
0
0
56
34
0
0
0
0
12
12
0
0
56
% Q
% Arg:
12
0
23
0
12
0
0
12
0
12
0
56
0
67
0
% R
% Ser:
67
0
0
0
0
0
0
67
12
56
23
23
12
23
12
% S
% Thr:
23
0
45
12
12
0
0
0
0
12
12
0
0
0
12
% T
% Val:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _