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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SEC63
All Species:
36.36
Human Site:
S414
Identified Species:
61.54
UniProt:
Q9UGP8
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UGP8
NP_009145.1
760
87997
S414
K
T
I
Q
D
L
V
S
L
K
E
S
D
R
H
Chimpanzee
Pan troglodytes
XP_001148185
760
87976
S414
K
T
I
Q
D
L
V
S
L
K
E
S
D
R
H
Rhesus Macaque
Macaca mulatta
XP_001091991
689
79874
F380
A
V
Q
G
L
Q
Q
F
K
S
P
L
L
Q
L
Dog
Lupus familis
XP_532252
850
96553
S504
K
T
I
Q
D
L
V
S
L
K
E
S
D
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHE0
760
87823
S414
K
T
I
Q
D
L
V
S
L
K
E
S
D
R
H
Rat
Rattus norvegicus
NP_001101107
727
83574
S414
K
S
I
Q
D
L
V
S
L
K
E
A
D
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511532
775
89598
S429
K
T
I
Q
D
L
V
S
L
K
E
S
D
R
Q
Chicken
Gallus gallus
XP_419802
759
87965
S414
K
S
I
Q
D
L
V
S
L
K
G
S
D
R
R
Frog
Xenopus laevis
NP_001088542
754
87189
S414
K
S
I
R
D
L
V
S
M
K
E
S
D
R
R
Zebra Danio
Brachydanio rerio
XP_002666271
754
86861
S413
R
T
L
Q
D
L
V
S
L
K
D
S
D
R
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648111
753
85835
Q413
K
N
L
Q
Q
F
A
Q
L
K
P
E
E
S
R
Honey Bee
Apis mellifera
XP_395961
751
87148
Q418
K
S
L
Q
Q
F
A
Q
L
K
G
E
E
R
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793617
800
91710
K402
K
S
I
S
Q
F
I
K
L
K
D
L
D
K
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P14906
663
75326
T355
I
A
L
G
A
I
N
T
F
K
C
I
V
Q
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
89.3
88.3
N.A.
96.1
91.8
N.A.
86.8
91.5
83.4
72.3
N.A.
44
42.3
N.A.
40.8
Protein Similarity:
100
99.8
89.8
89.1
N.A.
98.5
94.2
N.A.
91.8
95.7
91.8
84.7
N.A.
63.6
62.3
N.A.
59
P-Site Identity:
100
100
0
100
N.A.
100
86.6
N.A.
93.3
80
73.3
73.3
N.A.
26.6
33.3
N.A.
33.3
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
93.3
86.6
93.3
93.3
N.A.
40
53.3
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
23.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
8
0
15
0
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
0
65
0
0
0
0
0
15
0
72
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
50
15
15
0
0
% E
% Phe:
0
0
0
0
0
22
0
8
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
15
0
0
0
0
0
0
15
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% H
% Ile:
8
0
65
0
0
8
8
0
0
0
0
8
0
0
0
% I
% Lys:
79
0
0
0
0
0
0
8
8
93
0
0
0
8
0
% K
% Leu:
0
0
29
0
8
65
0
0
79
0
0
15
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% P
% Gln:
0
0
8
72
22
8
8
15
0
0
0
0
0
15
8
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
0
0
72
43
% R
% Ser:
0
36
0
8
0
0
0
65
0
8
0
58
0
8
0
% S
% Thr:
0
43
0
0
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
65
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _