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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PARP2 All Species: 49.39
Human Site: Y455 Identified Species: 90.56
UniProt: Q9UGN5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGN5 NP_001036083.1 583 66206 Y455 P E A P I T G Y M F G K G I Y
Chimpanzee Pan troglodytes XP_001137329 531 60196 E414 V E K D G E K E A F R E D L H
Rhesus Macaque Macaca mulatta XP_001088314 583 66217 Y455 P E A P I T G Y M F G K G I Y
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O88554 559 63378 Y431 P E A P I T G Y M F G K G I Y
Rat Rattus norvegicus P27008 1014 112642 Y889 P E A P V T G Y M F G K G I Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26446 1011 113502 Y886 P E A P V T G Y M F G K G I Y
Frog Xenopus laevis P31669 998 111108 Y872 P E A P V T G Y M F G K G I Y
Zebra Danio Brachydanio rerio XP_001923129 647 72923 Y519 A E A P V T G Y M F G K G I Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35875 994 113773 Y871 P E A P P T G Y M F G K G I Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N4H4 945 107988 Y815 P E A P V S G Y M F G K G V Y
Sea Urchin Strong. purpuratus XP_001199118 736 83866 Y610 P E A P V T G Y M F G K G V Y
Poplar Tree Populus trichocarpa
Maize Zea mays O50017 653 72977 Y528 P E A P V T G Y M F G K G V Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q11207 637 72157 Y513 P E A P V T G Y M F G K G V Y
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 97.4 N.A. N.A. 84.2 27.1 N.A. N.A. 27.9 25.7 55.6 N.A. 26.6 N.A. 23.8 42.5
Protein Similarity: 100 91 98.4 N.A. N.A. 90.7 40.2 N.A. N.A. 40.9 41 70.9 N.A. 40.8 N.A. 38.7 56.2
P-Site Identity: 100 13.3 100 N.A. N.A. 100 93.3 N.A. N.A. 93.3 93.3 86.6 N.A. 93.3 N.A. 80 86.6
P-Site Similarity: 100 33.3 100 N.A. N.A. 100 100 N.A. N.A. 100 100 93.3 N.A. 93.3 N.A. 100 100
Percent
Protein Identity: N.A. 42.5 N.A. 41.6 N.A. N.A.
Protein Similarity: N.A. 56.8 N.A. 57.6 N.A. N.A.
P-Site Identity: N.A. 86.6 N.A. 86.6 N.A. N.A.
P-Site Similarity: N.A. 100 N.A. 100 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 93 0 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 0 % D
% Glu: 0 100 0 0 0 8 0 8 0 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 100 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 93 0 0 0 93 0 93 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 24 0 0 0 0 0 0 0 0 62 0 % I
% Lys: 0 0 8 0 0 0 8 0 0 0 0 93 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % L
% Met: 0 0 0 0 0 0 0 0 93 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 85 0 0 93 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 85 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 62 0 0 0 0 0 0 0 0 31 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 93 0 0 0 0 0 0 93 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _