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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PARP2 All Species: 13.64
Human Site: T317 Identified Species: 25
UniProt: Q9UGN5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGN5 NP_001036083.1 583 66206 T317 P H D F G L R T P P L I R T Q
Chimpanzee Pan troglodytes XP_001137329 531 60196 A297 R A G Q H G R A L M E A C N E
Rhesus Macaque Macaca mulatta XP_001088314 583 66217 T317 P H D F G L R T P P L I R T Q
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O88554 559 63378 I293 P H D F G L S I P P V I R T E
Rat Rattus norvegicus P27008 1014 112642 K748 P H D F G M K K P P L L N N T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P26446 1011 113502 K745 P H D F G M K K P P L L S N L
Frog Xenopus laevis P31669 998 111108 K731 P H D F G M K K P P L L N N L
Zebra Danio Brachydanio rerio XP_001923129 647 72923 T381 P H D F G L R T P P I I R S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P35875 994 113773 L730 P H N F G V Q L P T L I E T H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N4H4 945 107988 V673 P H N F G M R V P E P I D S F
Sea Urchin Strong. purpuratus XP_001199118 736 83866 R475 P H N F G M Q R P P V I Q T K
Poplar Tree Populus trichocarpa
Maize Zea mays O50017 653 72977 T394 M R E F I I D T P Q K L K A K
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q11207 637 72157 T379 M S Q F V I D T P Q K L K Q K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 90.9 97.4 N.A. N.A. 84.2 27.1 N.A. N.A. 27.9 25.7 55.6 N.A. 26.6 N.A. 23.8 42.5
Protein Similarity: 100 91 98.4 N.A. N.A. 90.7 40.2 N.A. N.A. 40.9 41 70.9 N.A. 40.8 N.A. 38.7 56.2
P-Site Identity: 100 6.6 100 N.A. N.A. 73.3 53.3 N.A. N.A. 53.3 53.3 80 N.A. 53.3 N.A. 46.6 53.3
P-Site Similarity: 100 13.3 100 N.A. N.A. 86.6 73.3 N.A. N.A. 73.3 73.3 100 N.A. 73.3 N.A. 66.6 93.3
Percent
Protein Identity: N.A. 42.5 N.A. 41.6 N.A. N.A.
Protein Similarity: N.A. 56.8 N.A. 57.6 N.A. N.A.
P-Site Identity: N.A. 20 N.A. 20 N.A. N.A.
P-Site Similarity: N.A. 53.3 N.A. 46.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 8 0 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 0 0 54 0 0 0 16 0 0 0 0 0 8 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 8 8 0 8 0 24 % E
% Phe: 0 0 0 93 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 8 0 77 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 77 0 0 8 0 0 0 0 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 8 16 0 8 0 0 8 54 0 0 0 % I
% Lys: 0 0 0 0 0 0 24 24 0 0 16 0 16 0 24 % K
% Leu: 0 0 0 0 0 31 0 8 8 0 47 39 0 0 16 % L
% Met: 16 0 0 0 0 39 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 24 0 0 0 0 0 0 0 0 0 16 31 0 % N
% Pro: 77 0 0 0 0 0 0 0 93 62 8 0 0 0 0 % P
% Gln: 0 0 8 8 0 0 16 0 0 16 0 0 8 8 16 % Q
% Arg: 8 8 0 0 0 0 39 8 0 0 0 0 31 0 0 % R
% Ser: 0 8 0 0 0 0 8 0 0 0 0 0 8 16 0 % S
% Thr: 0 0 0 0 0 0 0 39 0 8 0 0 0 39 8 % T
% Val: 0 0 0 0 8 8 0 8 0 0 16 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _