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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PISD All Species: 7.58
Human Site: S32 Identified Species: 13.89
UniProt: Q9UG56 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UG56 NP_055153.1 408 46573 S32 P C E I T A L S Q S L Q P L R
Chimpanzee Pan troglodytes XP_515087 419 47798 E45 G G Q P P R L E E P G L G G L
Rhesus Macaque Macaca mulatta XP_001111773 409 46891 S32 H R E I T A L S Q S L Q P L W
Dog Lupus familis XP_534739 409 46776 S32 H C E N T T M S H F L Q P L R
Cat Felis silvestris
Mouse Mus musculus Q8BSF4 406 45908 R32 H Y E S T A T R H F L G T L Q
Rat Rattus norvegicus XP_002725046 409 45994 R32 H C D Y T A T R H F L G A L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515601 373 42661 Q31 A L R R R L G Q L S C M S R P
Chicken Gallus gallus XP_415253 409 46521 L32 L I R E N P C L R T P V L W K
Frog Xenopus laevis NP_001087912 411 47318 A36 S A T A S S W A R E Q Q P D Q
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651208 447 50470 L68 P A S K E A P L H H R R P Q H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10949 377 42469 S30 S P P M M L R S V R E L T N Q
Sea Urchin Strong. purpuratus XP_001180823 382 43384 E31 V P D S A E D E D I D L G D H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39006 500 56576 R54 R L F V Q Q R R S S G E I V D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 76.3 96.8 91.1 N.A. 84.5 84.5 N.A. 73 79.2 64.2 N.A. N.A. 39.3 N.A. 34 48.7
Protein Similarity: 100 78.5 97.3 94.1 N.A. 89.2 89.2 N.A. 79.1 86.3 72.9 N.A. N.A. 52.7 N.A. 50.7 60.5
P-Site Identity: 100 6.6 80 60 N.A. 33.3 33.3 N.A. 6.6 0 13.3 N.A. N.A. 20 N.A. 6.6 0
P-Site Similarity: 100 20 80 66.6 N.A. 40 46.6 N.A. 6.6 20 46.6 N.A. N.A. 26.6 N.A. 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 35 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 16 0 8 8 39 0 8 0 0 0 0 8 0 0 % A
% Cys: 0 24 0 0 0 0 8 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 16 0 0 0 8 0 8 0 8 0 0 16 8 % D
% Glu: 0 0 31 8 8 8 0 16 8 8 8 8 0 0 0 % E
% Phe: 0 0 8 0 0 0 0 0 0 24 0 0 0 0 0 % F
% Gly: 8 8 0 0 0 0 8 0 0 0 16 16 16 8 0 % G
% His: 31 0 0 0 0 0 0 0 31 8 0 0 0 0 16 % H
% Ile: 0 8 0 16 0 0 0 0 0 8 0 0 8 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 8 % K
% Leu: 8 16 0 0 0 16 24 16 8 0 39 24 8 39 8 % L
% Met: 0 0 0 8 8 0 8 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 8 8 0 0 0 0 0 0 0 0 8 0 % N
% Pro: 16 16 8 8 8 8 8 0 0 8 8 0 39 0 8 % P
% Gln: 0 0 8 0 8 8 0 8 16 0 8 31 0 8 31 % Q
% Arg: 8 8 16 8 8 8 16 24 16 8 8 8 0 8 16 % R
% Ser: 16 0 8 16 8 8 0 31 8 31 0 0 8 0 0 % S
% Thr: 0 0 8 0 39 8 16 0 0 8 0 0 16 0 0 % T
% Val: 8 0 0 8 0 0 0 0 8 0 0 8 0 8 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 8 % W
% Tyr: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _