KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APEX2
All Species:
6.97
Human Site:
S376
Identified Species:
19.17
UniProt:
Q9UBZ4
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.5
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBZ4
NP_055296.2
518
57401
S376
Q
N
K
A
Q
V
R
S
T
R
P
Q
P
S
Q
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001092143
518
57312
S376
Q
N
K
A
Q
V
H
S
T
R
P
R
P
S
Q
Dog
Lupus familis
XP_548620
487
54088
R347
H
Q
N
K
A
R
V
R
S
T
R
L
R
P
N
Cat
Felis silvestris
Mouse
Mus musculus
Q68G58
516
57321
S375
P
R
K
A
C
M
H
S
T
R
L
R
K
S
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510545
549
60839
E395
V
A
P
P
N
R
Q
E
K
R
N
S
A
E
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086779
517
57708
R372
G
A
D
I
S
T
V
R
K
R
P
S
D
K
L
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784420
596
66588
R405
S
R
L
D
I
G
K
R
E
G
Q
S
L
V
G
Poplar Tree
Populus trichocarpa
XP_002304326
617
69328
K391
K
A
C
S
E
S
I
K
R
S
F
N
E
C
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38207
520
59427
K379
T
T
Q
V
P
I
P
K
F
E
A
R
Y
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.1
81.4
N.A.
79.5
N.A.
N.A.
48
N.A.
52.1
N.A.
N.A.
N.A.
N.A.
N.A.
39.7
Protein Similarity:
100
N.A.
98.4
87.2
N.A.
86.2
N.A.
N.A.
63.3
N.A.
66.8
N.A.
N.A.
N.A.
N.A.
N.A.
55.3
P-Site Identity:
100
N.A.
86.6
0
N.A.
46.6
N.A.
N.A.
6.6
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
93.3
6.6
N.A.
60
N.A.
N.A.
20
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
25.7
N.A.
N.A.
N.A.
23.2
N.A.
Protein Similarity:
41.9
N.A.
N.A.
N.A.
40.9
N.A.
P-Site Identity:
0
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
34
0
34
12
0
0
0
0
0
12
0
12
0
0
% A
% Cys:
0
0
12
0
12
0
0
0
0
0
0
0
0
12
0
% C
% Asp:
0
0
12
12
0
0
0
0
0
0
0
0
12
0
0
% D
% Glu:
0
0
0
0
12
0
0
12
12
12
0
0
12
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
12
0
12
0
0
0
0
% F
% Gly:
12
0
0
0
0
12
0
0
0
12
0
0
0
0
12
% G
% His:
12
0
0
0
0
0
23
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
12
12
12
12
0
0
0
0
0
0
0
0
% I
% Lys:
12
0
34
12
0
0
12
23
23
0
0
0
12
23
12
% K
% Leu:
0
0
12
0
0
0
0
0
0
0
12
12
12
0
12
% L
% Met:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
23
12
0
12
0
0
0
0
0
12
12
0
0
12
% N
% Pro:
12
0
12
12
12
0
12
0
0
0
34
0
23
12
0
% P
% Gln:
23
12
12
0
23
0
12
0
0
0
12
12
0
0
34
% Q
% Arg:
0
23
0
0
0
23
12
34
12
56
12
34
12
0
0
% R
% Ser:
12
0
0
12
12
12
0
34
12
12
0
34
0
34
12
% S
% Thr:
12
12
0
0
0
12
0
0
34
12
0
0
0
0
0
% T
% Val:
12
0
0
12
0
23
23
0
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _