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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS7A All Species: 28.48
Human Site: S259 Identified Species: 44.76
UniProt: Q9UBW8 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBW8 NP_001157565.1 275 30277 S259 R Q P S K K A S K G K G L R G
Chimpanzee Pan troglodytes XP_001162737 248 27299 Q233 A A A A A T S Q D P E L S I C
Rhesus Macaque Macaca mulatta XP_001108537 275 30301 S259 R Q P S K K A S K G K G L R G
Dog Lupus familis XP_543849 275 30288 S259 R Q P S K K A S K G K G L R G
Cat Felis silvestris
Mouse Mus musculus Q9CZ04 275 30206 S259 R Q P S K K A S K G K G L R G
Rat Rattus norvegicus NP_001157563 275 30201 S259 R Q P S K K A S K G K G L R G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518093 661 70489 P485 R D R A P R S P A A E A Q A A
Chicken Gallus gallus NP_001025946 275 30386 S259 R Q T S K K T S K A K G L R G
Frog Xenopus laevis NP_001089653 264 29433 P249 P L T E Q R Q P T K K M S K V
Zebra Danio Brachydanio rerio XP_697089 266 29243 Q246 A S S Q E P R Q P G K K S S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V4S8 278 31049 S262 S E L R K K P S K L R N P R S
Honey Bee Apis mellifera XP_395310 282 30757 K263 S A P P D A K K K Q Q K V K G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785591 270 30197 S254 M K P S K K P S K M K G L R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94JU3 260 29450 E245 P S G V M D Y E E D G I R P K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SGS1 417 44522 S335 L L T S G G G S Y L S F R E G
Conservation
Percent
Protein Identity: 100 87.6 99.2 99.6 N.A. 98.9 98.9 N.A. 36.7 88.7 57 52 N.A. 40.6 43.6 N.A. 51.2
Protein Similarity: 100 88.3 100 99.6 N.A. 99.6 99.6 N.A. 39.7 94.5 76.3 68.3 N.A. 58.6 60.9 N.A. 70.1
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 6.6 80 6.6 13.3 N.A. 33.3 20 N.A. 73.3
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 33.3 80 26.6 20 N.A. 46.6 40 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. 29.8 N.A. 24.9
Protein Similarity: N.A. N.A. N.A. 50.1 N.A. 40.5
P-Site Identity: N.A. N.A. N.A. 0 N.A. 20
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 14 7 14 7 7 34 0 7 14 0 7 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 7 0 0 7 7 0 0 7 7 0 0 0 0 0 % D
% Glu: 0 7 0 7 7 0 0 7 7 0 14 0 0 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 0 0 7 0 7 7 7 0 0 40 7 47 0 0 60 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 7 0 7 0 % I
% Lys: 0 7 0 0 54 54 7 7 60 7 60 14 0 14 14 % K
% Leu: 7 14 7 0 0 0 0 0 0 14 0 7 47 0 0 % L
% Met: 7 0 0 0 7 0 0 0 0 7 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % N
% Pro: 14 0 47 7 7 7 14 14 7 7 0 0 7 7 0 % P
% Gln: 0 40 0 7 7 0 7 14 0 7 7 0 7 0 0 % Q
% Arg: 47 0 7 7 0 14 7 0 0 0 7 0 14 54 0 % R
% Ser: 14 14 7 54 0 0 14 60 0 0 7 0 20 7 7 % S
% Thr: 0 0 20 0 0 7 7 0 7 0 0 0 0 0 0 % T
% Val: 0 0 0 7 0 0 0 0 0 0 0 0 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _