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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSZ
All Species:
7.88
Human Site:
Y238
Identified Species:
19.26
UniProt:
Q9UBR2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBR2
NP_001327.2
303
33868
Y238
A
E
Y
Q
D
T
T
Y
I
N
H
V
V
S
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_854795
375
41541
Y310
A
E
Y
Q
E
Q
A
Y
I
N
H
V
I
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WUU7
306
33978
V240
A
E
H
Q
D
Q
A
V
I
N
H
I
I
S
V
Rat
Rattus norvegicus
Q9R1T3
306
34176
I240
T
E
Y
Q
N
Q
A
I
I
N
H
I
I
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P09648
218
23945
Y154
F
Y
Q
S
G
I
Y
Y
E
P
D
C
S
S
E
Frog
Xenopus laevis
NP_001088101
296
32990
M229
A
E
F
Q
P
S
A
M
I
N
H
I
V
S
V
Zebra Danio
Brachydanio rerio
NP_001006043
301
33586
Y230
S
E
Y
V
Q
E
P
Y
I
N
H
I
V
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
G302
V
H
T
G
G
K
L
G
G
G
H
A
V
K
L
Sea Urchin
Strong. purpuratus
XP_788187
293
31563
I225
Y
A
E
Y
Q
S
T
I
S
I
N
H
I
V
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O65493
355
39599
P267
V
K
A
L
A
H
Q
P
V
S
V
A
I
E
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
67.7
N.A.
83
83.9
N.A.
N.A.
25
71.6
64
N.A.
N.A.
N.A.
23.4
56.1
Protein Similarity:
100
N.A.
N.A.
72.2
N.A.
89.5
90.1
N.A.
N.A.
38.2
79.8
76.5
N.A.
N.A.
N.A.
36.4
70.6
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
60
53.3
N.A.
N.A.
13.3
60
60
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
80
73.3
N.A.
N.A.
13.3
80
73.3
N.A.
N.A.
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
10
10
0
10
0
40
0
0
0
0
20
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
0
0
0
0
20
0
0
0
0
0
10
0
0
0
0
% D
% Glu:
0
60
10
0
10
10
0
0
10
0
0
0
0
10
10
% E
% Phe:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
10
20
0
0
10
10
10
0
0
0
0
0
% G
% His:
0
10
10
0
0
10
0
0
0
0
70
10
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
20
60
10
0
40
50
0
0
% I
% Lys:
0
10
0
0
0
10
0
0
0
0
0
0
0
10
0
% K
% Leu:
0
0
0
10
0
0
10
0
0
0
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
60
10
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
10
10
0
10
0
0
0
0
0
% P
% Gln:
0
0
10
50
20
30
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
0
10
0
20
0
0
10
10
0
0
10
70
10
% S
% Thr:
10
0
10
0
0
10
20
0
0
0
0
0
0
0
0
% T
% Val:
20
0
0
10
0
0
0
10
10
0
10
20
40
10
60
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
10
40
10
0
0
10
40
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _