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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: METTL1 All Species: 19.39
Human Site: T34 Identified Species: 28.44
UniProt: Q9UBP6 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBP6 NP_005362.3 276 31471 T34 S N P M A D H T L R Y P V K P
Chimpanzee Pan troglodytes XP_001167352 301 34100 T59 S N P I A D H T L R Y P V K P
Rhesus Macaque Macaca mulatta XP_001116496 301 34160 T59 S N P M A D H T L R Y P V K P
Dog Lupus familis XP_849422 247 28132 K34 T H D D P K D K K E K R A Q A
Cat Felis silvestris
Mouse Mus musculus Q9Z120 268 30585 M38 Y P V K P E E M D W S E L Y P
Rat Rattus norvegicus XP_001054797 267 30550 M37 Y P V K P E E M D W S E L Y P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516298 226 25512 F21 W S E L F P A F C P P L T K Q
Chicken Gallus gallus
Frog Xenopus laevis Q6NU94 273 31824 T36 S N P M A D H T F Q Y P V K P
Zebra Danio Brachydanio rerio Q5XJ57 241 27917 M34 Y P V C P E Q M D W S P L Y P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O77263 256 29406 Y35 G L P Q K R Y Y R Q R A H S N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23126 256 30022 A34 K K H Y R Q R A H S N P H S D
Sea Urchin Strong. purpuratus XP_790960 406 47124 S100 A F F K N N T S S P H D L Y P
Poplar Tree Populus trichocarpa
Maize Zea mays B6SHG7 255 29101 P34 P L S D S H F P V P I S P E E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8GXB7 251 28800 H35 S N P L S D S H F P I P I S P
Baker's Yeast Sacchar. cerevisiae Q12009 286 33373 E41 N E S S L V Q E G Q K I D L P
Red Bread Mold Neurospora crassa Q7RZC1 293 33715 S45 A N P F S D H S L I Y P P T P
Conservation
Percent
Protein Identity: 100 90.6 90.6 81.5 N.A. 88 88.4 N.A. 64.8 N.A. 69.5 67.7 N.A. 47.4 N.A. 50.7 42.3
Protein Similarity: 100 91.3 91 83.6 N.A. 92.3 90.9 N.A. 72 N.A. 80 76.4 N.A. 59.7 N.A. 64.8 51.2
P-Site Identity: 100 93.3 100 0 N.A. 6.6 6.6 N.A. 6.6 N.A. 86.6 13.3 N.A. 6.6 N.A. 6.6 6.6
P-Site Similarity: 100 100 100 20 N.A. 20 20 N.A. 20 N.A. 93.3 26.6 N.A. 20 N.A. 6.6 40
Percent
Protein Identity: N.A. 52.5 N.A. 50 46.8 48.8
Protein Similarity: N.A. 68.4 N.A. 68.4 61.5 66.2
P-Site Identity: N.A. 0 N.A. 40 6.6 53.3
P-Site Similarity: N.A. 20 N.A. 60 20 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 0 25 0 7 7 0 0 0 7 7 0 7 % A
% Cys: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 0 7 13 0 38 7 0 19 0 0 7 7 0 7 % D
% Glu: 0 7 7 0 0 19 13 7 0 7 0 13 0 7 7 % E
% Phe: 0 7 7 7 7 0 7 7 13 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % G
% His: 0 7 7 0 0 7 32 7 7 0 7 0 13 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 0 7 13 7 7 0 0 % I
% Lys: 7 7 0 19 7 7 0 7 7 0 13 0 0 32 0 % K
% Leu: 0 13 0 13 7 0 0 0 25 0 0 7 25 7 0 % L
% Met: 0 0 0 19 0 0 0 19 0 0 0 0 0 0 0 % M
% Asn: 7 38 0 0 7 7 0 0 0 0 7 0 0 0 7 % N
% Pro: 7 19 44 0 25 7 0 7 0 25 7 50 13 0 69 % P
% Gln: 0 0 0 7 0 7 13 0 0 19 0 0 0 7 7 % Q
% Arg: 0 0 0 0 7 7 7 0 7 19 7 7 0 0 0 % R
% Ser: 32 7 13 7 19 0 7 13 7 7 19 7 0 19 0 % S
% Thr: 7 0 0 0 0 0 7 25 0 0 0 0 7 7 0 % T
% Val: 0 0 19 0 0 7 0 0 7 0 0 0 25 0 0 % V
% Trp: 7 0 0 0 0 0 0 0 0 19 0 0 0 0 0 % W
% Tyr: 19 0 0 7 0 0 7 7 0 0 32 0 0 25 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _