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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SAE1 All Species: 21.82
Human Site: T205 Identified Species: 34.29
UniProt: Q9UBE0 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBE0 NP_005491.1 346 38450 T205 K L D S S E T T M V K K K V V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001109956 343 37452 T206 K L D S S E T T M V K K K V V
Dog Lupus familis XP_533632 346 38307 T205 K L D S S E T T M V K K K V V
Cat Felis silvestris
Mouse Mus musculus Q9R1T2 350 38602 T209 K L D S S E T T M V K K K V L
Rat Rattus norvegicus Q6AXQ0 349 38494 T208 K L D S S E T T M V K K K V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521826 313 34323 L199 S S D K A K S L L K R T T S D
Chicken Gallus gallus Q5ZIE6 535 60465 D203 H I Q S Y D L D H M D K K D H
Frog Xenopus laevis Q8JGT5 344 38228 I203 K I D P T E T I L V K K K V Q
Zebra Danio Brachydanio rerio Q6IQS6 348 39058 T206 P K I D P N E T T M V K K T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VTE9 524 58698 T207 H L D G T E V T S K V P W L L
Honey Bee Apis mellifera XP_394348 287 32309 D177 M T H E Y V E D V V Q T K K V
Nematode Worm Caenorhab. elegans Q17820 343 38720 V203 V T V D E E F V L E T F S Y P
Sea Urchin Strong. purpuratus XP_794964 338 37736 V200 D P T E T V F V K K T M I F H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P42744 540 60016 N213 F V E T I D L N V S E P A A A
Baker's Yeast Sacchar. cerevisiae Q06624 347 39255 E202 E V T T R K D E E D E K K T Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 82.3 96.2 N.A. 92.2 91.4 N.A. 77.1 20.9 74.8 68.6 N.A. 21.3 41.6 32 48.5
Protein Similarity: 100 N.A. 86.7 98.8 N.A. 97.4 96.2 N.A. 84.6 36.2 86.4 82.7 N.A. 36 60.9 50.5 65.9
P-Site Identity: 100 N.A. 100 100 N.A. 93.3 93.3 N.A. 6.6 20 60 20 N.A. 26.6 20 6.6 0
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 40 40 80 33.3 N.A. 46.6 33.3 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 22.4 33.7 N.A.
Protein Similarity: N.A. N.A. N.A. 37.5 55.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 0 0 0 0 0 0 0 7 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 54 14 0 14 7 14 0 7 7 0 0 7 7 % D
% Glu: 7 0 7 14 7 54 14 7 7 7 14 0 0 0 0 % E
% Phe: 7 0 0 0 0 0 14 0 0 0 0 7 0 7 0 % F
% Gly: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 14 0 7 0 0 0 0 0 7 0 0 0 0 0 14 % H
% Ile: 0 14 7 0 7 0 0 7 0 0 0 0 7 0 7 % I
% Lys: 40 7 0 7 0 14 0 0 7 20 40 60 67 7 0 % K
% Leu: 0 40 0 0 0 0 14 7 20 0 0 0 0 7 20 % L
% Met: 7 0 0 0 0 0 0 0 34 14 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 7 0 7 0 0 0 0 0 0 0 % N
% Pro: 7 7 0 7 7 0 0 0 0 0 0 14 0 0 7 % P
% Gln: 0 0 7 0 0 0 0 0 0 0 7 0 0 0 7 % Q
% Arg: 0 0 0 0 7 0 0 0 0 0 7 0 0 0 0 % R
% Ser: 7 7 0 40 34 0 7 0 7 7 0 0 7 7 0 % S
% Thr: 0 14 14 14 20 0 40 47 7 0 14 14 7 14 0 % T
% Val: 7 14 7 0 0 14 7 14 14 47 14 0 0 40 27 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % W
% Tyr: 0 0 0 0 14 0 0 0 0 0 0 0 0 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _