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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
31.82
Human Site:
Y484
Identified Species:
58.33
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
Y484
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
N
K
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
Y483
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
N
K
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
Y483
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
N
K
Dog
Lupus familis
XP_854775
1113
124420
Y482
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
Y480
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
N
K
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
Y476
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
N
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
Y493
D
N
G
Y
Y
L
P
Y
Y
K
R
E
R
S
K
Chicken
Gallus gallus
XP_420868
1085
121590
Y462
D
N
G
Y
Y
L
P
Y
Y
K
R
D
R
S
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
Q483
T
G
D
L
N
G
P
Q
E
C
S
T
Q
N
N
Honey Bee
Apis mellifera
XP_001123105
822
95490
N262
I
K
T
N
G
Y
K
N
L
K
E
I
N
L
F
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
H489
S
S
P
R
M
I
E
H
L
S
S
T
E
S
A
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
Q573
N
G
Y
Y
L
L
H
Q
L
T
P
M
H
M
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
86.6
N.A.
0
N.A.
13.3
6.6
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
N.A.
0
N.A.
20
6.6
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
62
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
8
0
8
54
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
16
62
0
8
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% H
% Ile:
8
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
8
0
0
0
0
8
0
0
70
0
0
0
0
62
% K
% Leu:
0
0
0
8
8
70
0
0
24
0
0
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
8
0
8
8
% M
% Asn:
8
62
0
8
8
0
0
8
0
0
0
0
8
47
8
% N
% Pro:
0
0
8
0
0
0
70
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
16
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
62
0
62
0
0
% R
% Ser:
8
8
0
0
0
0
0
0
0
8
16
0
0
31
0
% S
% Thr:
8
0
8
0
0
0
0
0
0
8
0
16
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
70
62
8
0
62
62
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _