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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
22.42
Human Site:
S685
Identified Species:
41.11
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
S685
E
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
S684
E
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
S684
A
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Dog
Lupus familis
XP_854775
1113
124420
L682
D
E
S
T
D
W
P
L
S
S
P
S
P
M
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
S681
E
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
S677
E
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
S694
E
S
T
D
W
P
L
S
S
P
S
P
M
D
A
Chicken
Gallus gallus
XP_420868
1085
121590
L662
D
E
S
T
D
W
P
L
S
S
P
S
P
M
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
Q733
H
E
L
S
T
S
I
Q
I
E
T
P
D
D
S
Honey Bee
Apis mellifera
XP_001123105
822
95490
P410
R
Y
L
T
D
F
E
P
V
D
C
L
G
K
G
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
A653
R
V
L
R
E
A
R
A
L
A
M
F
D
H
P
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
K785
D
T
P
A
F
F
N
K
N
S
E
L
I
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
93.3
6.6
N.A.
100
100
N.A.
100
6.6
N.A.
0
N.A.
13.3
0
0
0
P-Site Similarity:
100
100
93.3
20
N.A.
100
100
N.A.
100
20
N.A.
0
N.A.
33.3
0
6.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
8
0
8
0
8
0
0
0
0
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
24
0
0
47
24
0
0
0
0
8
0
0
16
54
16
% D
% Glu:
39
24
0
0
8
0
8
0
0
8
8
0
0
0
0
% E
% Phe:
0
0
0
0
8
16
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
8
0
8
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% K
% Leu:
0
0
24
0
0
0
47
16
8
0
0
16
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
47
16
0
% M
% Asn:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
8
% N
% Pro:
0
0
8
0
0
47
16
8
0
47
16
54
16
0
8
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
16
0
0
8
0
0
8
0
0
0
0
0
0
8
0
% R
% Ser:
0
47
16
8
0
8
0
47
62
24
47
16
0
0
8
% S
% Thr:
0
8
47
24
8
0
0
0
0
0
8
0
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
47
16
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _