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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
21.82
Human Site:
S575
Identified Species:
40
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
S575
V
S
G
E
A
N
D
S
S
W
N
D
I
K
N
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
S574
V
S
G
E
A
N
D
S
S
W
N
D
I
K
N
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
S574
V
S
G
E
A
N
D
S
N
W
N
D
I
K
N
Dog
Lupus familis
XP_854775
1113
124420
S573
V
S
G
E
A
K
D
S
S
W
N
D
I
K
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
N571
V
S
A
D
V
S
D
N
S
W
N
D
M
K
Y
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
N567
V
S
A
D
N
S
D
N
S
W
N
D
I
K
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
S584
I
S
G
E
I
S
D
S
S
W
S
D
I
K
T
Chicken
Gallus gallus
XP_420868
1085
121590
T553
A
C
G
D
A
K
D
T
S
W
S
D
V
K
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
S624
Q
A
N
Q
R
T
I
S
E
S
T
T
H
S
G
Honey Bee
Apis mellifera
XP_001123105
822
95490
L343
T
N
S
D
L
I
L
L
E
E
K
Q
K
L
F
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
D572
T
D
I
D
T
D
E
D
S
F
S
N
D
E
K
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
D663
K
P
S
S
P
E
L
D
R
S
S
D
P
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
93.3
93.3
N.A.
53.3
60
N.A.
66.6
53.3
N.A.
0
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
86.6
N.A.
86.6
80
N.A.
0
N.A.
20
13.3
53.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
0
39
0
0
0
0
0
0
0
0
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
39
0
8
62
16
0
0
0
70
8
0
0
% D
% Glu:
0
0
0
39
0
8
8
0
16
8
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% F
% Gly:
0
0
47
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% H
% Ile:
8
0
8
0
8
8
8
0
0
0
0
0
47
0
0
% I
% Lys:
8
0
0
0
0
16
0
0
0
0
8
0
8
62
8
% K
% Leu:
0
0
0
0
8
0
16
8
0
0
0
0
0
16
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
8
0
8
24
0
16
8
0
47
8
0
0
39
% N
% Pro:
0
8
0
0
8
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
8
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
54
16
8
0
24
0
47
62
16
31
0
0
8
0
% S
% Thr:
16
0
0
0
8
8
0
8
0
0
8
8
0
0
8
% T
% Val:
47
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
62
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _