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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP39A1 All Species: 16.97
Human Site: S259 Identified Species: 33.94
UniProt: Q9NYL5 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NYL5 NP_057677.2 469 54116 S259 D I V E T E T S K E N S P N Y
Chimpanzee Pan troglodytes XP_518518 469 54055 S259 D I V E T E T S K E N S P N Y
Rhesus Macaque Macaca mulatta XP_001102611 469 54028 S259 D I V E T E T S K E N S P N Y
Dog Lupus familis XP_538946 469 54328 K259 D I V E M E R K E E K S P N Y
Cat Felis silvestris
Mouse Mus musculus Q9JKJ9 470 53556 T260 L E V V E T E T R Q Y S P N Y
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511640 415 47952 W218 S Y A V L L L W A S Q S N A V
Chicken Gallus gallus XP_420063 419 47287 W222 N Y G L L M L W A S Q A N A V
Frog Xenopus laevis NP_001083508 504 57241 L293 S G N Q H K A L T D V E I M A
Zebra Danio Brachydanio rerio NP_001025360 464 52846 S255 Q H L A A S I S E Q Y L P N Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789944 362 41142 Y172 L I F F L A G Y E T T N T T C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LTL8 498 56791 T287 Q G D S F K L T I D N L K G I
Baker's Yeast Sacchar. cerevisiae P10614 530 60702 T300 Y K D G V K M T D Q E I A N L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97 84.8 N.A. 74.8 N.A. N.A. 62 49.2 21.2 49.2 N.A. N.A. N.A. N.A. 23.4
Protein Similarity: 100 99.5 97.8 92.3 N.A. 86.1 N.A. N.A. 74.1 65 40.8 67.3 N.A. N.A. N.A. N.A. 39.4
P-Site Identity: 100 100 100 66.6 N.A. 33.3 N.A. N.A. 6.6 0 0 26.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 73.3 N.A. 53.3 N.A. N.A. 6.6 13.3 20 46.6 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.9 N.A.
Protein Similarity: N.A. N.A. N.A. 44.3 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 9 9 9 9 0 17 0 0 9 9 17 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 34 0 17 0 0 0 0 0 9 17 0 0 0 0 0 % D
% Glu: 0 9 0 34 9 34 9 0 25 34 9 9 0 0 0 % E
% Phe: 0 0 9 9 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 17 9 9 0 0 9 0 0 0 0 0 0 9 0 % G
% His: 0 9 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 42 0 0 0 0 9 0 9 0 0 9 9 0 9 % I
% Lys: 0 9 0 0 0 25 0 9 25 0 9 0 9 0 0 % K
% Leu: 17 0 9 9 25 9 25 9 0 0 0 17 0 0 9 % L
% Met: 0 0 0 0 9 9 9 0 0 0 0 0 0 9 0 % M
% Asn: 9 0 9 0 0 0 0 0 0 0 34 9 17 59 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 50 0 0 % P
% Gln: 17 0 0 9 0 0 0 0 0 25 17 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 9 0 9 0 0 0 0 0 0 % R
% Ser: 17 0 0 9 0 9 0 34 0 17 0 50 0 0 0 % S
% Thr: 0 0 0 0 25 9 25 25 9 9 9 0 9 9 0 % T
% Val: 0 0 42 17 9 0 0 0 0 0 9 0 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % W
% Tyr: 9 17 0 0 0 0 0 9 0 0 17 0 0 0 50 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _