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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MKS1
All Species:
15.45
Human Site:
T227
Identified Species:
34
UniProt:
Q9NXB0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXB0
NP_060247.2
559
64528
T227
K
Y
E
H
V
L
C
T
L
K
V
D
S
N
G
Chimpanzee
Pan troglodytes
XP_001172592
559
64593
T227
K
Y
E
H
V
L
C
T
L
K
V
D
S
N
G
Rhesus Macaque
Macaca mulatta
XP_001103807
582
67318
T250
K
Y
E
H
V
L
C
T
L
K
V
D
S
N
G
Dog
Lupus familis
XP_548230
625
71517
T293
K
Y
E
H
V
L
C
T
L
K
V
D
S
N
G
Cat
Felis silvestris
Mouse
Mus musculus
Q5SW45
561
64397
I227
V
H
E
H
V
L
C
I
L
K
V
D
S
N
G
Rat
Rattus norvegicus
Q499Q5
561
64504
V227
I
H
E
H
V
L
C
V
L
K
V
D
S
N
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520585
416
47671
S95
R
C
Q
K
V
T
S
S
A
Q
E
V
P
S
F
Chicken
Gallus gallus
XP_415705
524
60060
P203
N
G
V
I
T
V
K
P
D
F
T
G
S
K
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572804
699
80065
L327
R
Y
D
P
E
Q
G
L
L
Y
V
Y
P
D
F
Honey Bee
Apis mellifera
XP_001120316
448
52853
A127
K
P
Y
K
T
K
L
A
I
R
N
Q
T
A
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787637
523
59905
R202
D
P
M
L
M
Q
R
R
T
N
L
V
V
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
91.4
81.7
N.A.
88.9
86.9
N.A.
60.2
67
N.A.
N.A.
N.A.
22.3
26.8
N.A.
42.2
Protein Similarity:
100
99.4
93.1
86.2
N.A.
95
94.4
N.A.
68.1
78.1
N.A.
N.A.
N.A.
36.4
42.4
N.A.
61.1
P-Site Identity:
100
100
100
100
N.A.
80
80
N.A.
6.6
13.3
N.A.
N.A.
N.A.
20
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
40
20
N.A.
N.A.
N.A.
40
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
10
0
0
0
0
10
0
% A
% Cys:
0
10
0
0
0
0
55
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
0
0
0
0
10
0
0
55
0
10
0
% D
% Glu:
0
0
55
0
10
0
0
0
0
0
10
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
19
% F
% Gly:
0
10
0
0
0
0
10
0
0
0
0
10
0
0
64
% G
% His:
0
19
0
55
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
10
0
0
0
10
10
0
0
0
0
0
0
% I
% Lys:
46
0
0
19
0
10
10
0
0
55
0
0
0
10
0
% K
% Leu:
0
0
0
10
0
55
10
10
64
0
10
0
0
0
10
% L
% Met:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
10
10
0
0
55
0
% N
% Pro:
0
19
0
10
0
0
0
10
0
0
0
0
19
0
0
% P
% Gln:
0
0
10
0
0
19
0
0
0
10
0
10
0
0
0
% Q
% Arg:
19
0
0
0
0
0
10
10
0
10
0
0
0
0
10
% R
% Ser:
0
0
0
0
0
0
10
10
0
0
0
0
64
10
0
% S
% Thr:
0
0
0
0
19
10
0
37
10
0
10
0
10
0
0
% T
% Val:
10
0
10
0
64
10
0
10
0
0
64
19
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
46
10
0
0
0
0
0
0
10
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _