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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK4
All Species:
23.64
Human Site:
Y354
Identified Species:
47.27
UniProt:
Q9NWZ3
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWZ3
NP_001107654.1
460
51530
Y354
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Chimpanzee
Pan troglodytes
XP_001166114
460
51588
Y354
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Rhesus Macaque
Macaca mulatta
NP_001129573
460
51601
Y354
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Dog
Lupus familis
XP_543727
460
51521
Y354
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K2
459
50853
Y354
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Rat
Rattus norvegicus
NP_001100261
461
51050
Y356
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521647
280
31332
G196
S
I
G
G
N
K
M
G
E
G
G
F
G
V
V
Chicken
Gallus gallus
NP_001025909
373
40585
H289
E
I
M
A
K
C
K
H
E
N
L
V
E
L
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956457
382
41751
T298
R
L
A
C
A
E
H
T
P
A
L
T
W
R
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784716
406
45182
F319
K
K
T
D
V
Y
S
F
G
L
V
L
L
E
I
Poplar Tree
Populus trichocarpa
XP_002322185
562
63055
G424
T
R
L
V
G
T
P
G
Y
I
A
P
E
S
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_198715
880
97935
G696
T
V
V
K
G
T
F
G
Y
L
D
P
E
Y
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.6
92.8
N.A.
83.9
84.3
N.A.
45.2
47.3
N.A.
39.1
N.A.
N.A.
N.A.
N.A.
33.9
Protein Similarity:
100
99.5
99.1
96.3
N.A.
90.8
91.9
N.A.
51.9
58.2
N.A.
54.7
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
13.3
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
26.6
N.A.
20
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
28.1
N.A.
N.A.
21.5
N.A.
N.A.
Protein Similarity:
47.5
N.A.
N.A.
34.4
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
9
0
50
0
0
59
9
0
50
0
0
% A
% Cys:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
0
0
0
0
0
9
0
0
0
0
% D
% Glu:
9
0
0
0
0
9
0
0
17
0
0
50
25
9
0
% E
% Phe:
0
0
0
0
0
0
9
9
0
0
0
9
0
0
0
% F
% Gly:
0
0
9
59
17
0
0
25
9
9
9
0
9
0
0
% G
% His:
0
0
0
0
0
0
9
9
0
0
0
0
0
0
0
% H
% Ile:
0
67
0
0
0
0
0
0
0
9
0
0
0
0
9
% I
% Lys:
9
9
0
9
9
9
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
9
9
0
0
0
0
0
0
17
17
9
9
59
9
% L
% Met:
0
0
9
0
0
0
9
0
50
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
9
% N
% Pro:
0
0
0
0
0
0
9
0
9
0
50
17
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
59
9
0
0
0
0
0
0
0
0
0
0
0
9
50
% R
% Ser:
9
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% S
% Thr:
17
0
9
0
50
67
0
9
0
0
0
9
0
0
0
% T
% Val:
0
9
59
9
9
0
0
0
0
0
9
9
0
9
17
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
0
0
0
9
0
50
17
0
0
0
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _