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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK4
All Species:
16.36
Human Site:
T133
Identified Species:
32.73
UniProt:
Q9NWZ3
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWZ3
NP_001107654.1
460
51530
T133
P
F
C
D
K
D
R
T
L
M
T
P
V
Q
N
Chimpanzee
Pan troglodytes
XP_001166114
460
51588
T133
P
F
Y
D
K
D
R
T
L
M
T
P
V
Q
N
Rhesus Macaque
Macaca mulatta
NP_001129573
460
51601
T133
P
F
Y
D
K
D
R
T
L
M
T
P
L
Q
N
Dog
Lupus familis
XP_543727
460
51521
T133
P
L
N
G
K
D
R
T
F
V
L
P
V
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K2
459
50853
T133
P
C
Q
E
K
D
R
T
S
V
M
P
M
P
K
Rat
Rattus norvegicus
NP_001100261
461
51050
V135
Q
E
K
N
R
T
T
V
T
P
A
L
A
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521647
280
31332
Chicken
Gallus gallus
NP_001025909
373
40585
R97
Y
S
Q
A
H
I
R
R
F
E
A
F
V
Q
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956457
382
41751
C106
L
L
P
D
H
S
V
C
H
A
H
T
G
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784716
406
45182
K127
M
T
E
G
F
N
Q
K
K
V
K
D
G
G
C
Poplar Tree
Populus trichocarpa
XP_002322185
562
63055
S205
L
S
A
V
T
L
F
S
V
C
S
L
L
L
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_198715
880
97935
T478
N
E
S
S
V
D
T
T
N
K
P
S
T
N
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.6
92.8
N.A.
83.9
84.3
N.A.
45.2
47.3
N.A.
39.1
N.A.
N.A.
N.A.
N.A.
33.9
Protein Similarity:
100
99.5
99.1
96.3
N.A.
90.8
91.9
N.A.
51.9
58.2
N.A.
54.7
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
93.3
86.6
60
N.A.
40
6.6
N.A.
0
20
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
93.3
66.6
N.A.
60
20
N.A.
0
20
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
28.1
N.A.
N.A.
21.5
N.A.
N.A.
Protein Similarity:
47.5
N.A.
N.A.
34.4
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
9
0
0
0
0
0
9
17
0
9
0
0
% A
% Cys:
0
9
9
0
0
0
0
9
0
9
0
0
0
0
9
% C
% Asp:
0
0
0
34
0
50
0
0
0
0
0
9
0
0
0
% D
% Glu:
0
17
9
9
0
0
0
0
0
9
0
0
0
0
0
% E
% Phe:
0
25
0
0
9
0
9
0
17
0
0
9
0
0
9
% F
% Gly:
0
0
0
17
0
0
0
0
0
0
0
0
17
9
0
% G
% His:
0
0
0
0
17
0
0
0
9
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
42
0
0
9
9
9
9
0
0
0
17
% K
% Leu:
17
17
0
0
0
9
0
0
25
0
9
17
17
9
0
% L
% Met:
9
0
0
0
0
0
0
0
0
25
9
0
9
0
9
% M
% Asn:
9
0
9
9
0
9
0
0
9
0
0
0
0
9
34
% N
% Pro:
42
0
9
0
0
0
0
0
0
9
9
42
0
9
0
% P
% Gln:
9
0
17
0
0
0
9
0
0
0
0
0
0
50
0
% Q
% Arg:
0
0
0
0
9
0
50
9
0
0
0
0
0
0
0
% R
% Ser:
0
17
9
9
0
9
0
9
9
0
9
9
0
9
9
% S
% Thr:
0
9
0
0
9
9
17
50
9
0
25
9
9
0
0
% T
% Val:
0
0
0
9
9
0
9
9
9
25
0
0
34
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _